Perioperative risk factors of progressive chronic kidney disease following liver transplantation: analyses of a 10-year follow-up single-center cohort

Annals of Surgical Treatment and Research
Kyungho LeeWooseong Huh

Abstract

The incidence of chronic kidney disease (CKD) has been increasing due to improved survival after liver transplantation (LT). Risk factors of kidney injury after LT, especially perioperative management factors, are potentially modifiable. We investigated the risk factors associated with progressive CKD for 10 years after LT. This retrospective cohort study included 292 adult patients who underwent LT at a tertiary referral hospital between 2000 and 2008. Renal function was assessed by the e stimated glomerular filtration rate (eGFR) using the Modification of Diet in Renal Disease formula. The area under the curve of serial eGFR (AUCeGFR) was calculated for each patient to assess the trajectory of eGFR over the 10 years. Low AUCeGFR was considered progressive CKD. Linear regression analyses were performed to examine the associations between the variables and AUCeGFR. Multivariable analysis showed that older age (regression coefficient = -0.53, P < 0.001), diabetes mellitus (DM) (regression coefficient = -6.93, P = 0.007), preoperative proteinuria (regression coefficient = -16.11, P < 0.001), preoperative acute kidney injury (AKI) (regression coefficient = -14.35, P < 0.001), postoperative AKI (regression coefficient = -3.86, P = ...Continue Reading

References

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Jun 4, 2013·Lancet·Vivekanand JhaChih-Wei Yang
Jul 17, 2013·Transplant International : Official Journal of the European Society for Organ Transplantation·Masashi UtsumiToshiyoshi Fujiwara
Jun 4, 2014·JAMA : the Journal of the American Medical Association·Josef CoreshAndrew S Levey
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Jul 3, 2018·Annals of Surgical Treatment and Research·Ha Yeon KimGaab Soo Kim
Mar 20, 2019·Journal of Clinical Medicine·Charat ThongprayoonWisit Cheungpasitporn

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Citations

Jun 12, 2021·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Fabrizio FabriziPiergiorgio Messa
Nov 16, 2021·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Reyhane Hizomi AraniMohammad Hossein Shojamoradi

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