Perioperative search for circulating tumor cells in patients undergoing radical cystectomy for bladder cancer.

European Journal of Medical Research
A KarlC Schindlbeck

Abstract

Despite having an organ confined tumor stage at the time of radical cystectomy, a certain number of bladder cancer patients will develop local or distant metastases over time. Currently there are no reliable serum markers for monitoring and evaluating risk profiles of urothelial cancers. Several studies suggest that detection of Circulating Tumor Cells (CTC) may correlate with disease status and prognosis at baseline and early in the treatment of cancers. The presence of CTCs in whole blood before and during radical cystectomy could provide further information on disease status, and could be used as an indicator to determine the need for adjuvant or even perioperative chemotherapy. From 03/2009 to 05/2009, five patients with histologically proven transitional cell carcinoma of the urinary bladder participated in this study. All patients were admitted to the hospital for radical cystectomy (rCx). A standard or extended lymph node dissection was performed in all cases. Preoperative CT or MRI scans revealed no distant or local metastases. Median age was 66.8 years (55-81 yrs). After obtaining informed consent from each patient, approximately 30 mL of peripheral blood was taken immediately before rCx and again during surgical remov...Continue Reading

References

Jun 1, 1979·Cancer·G R ProutW U Shipley
Dec 23, 2000·The Journal of Urology·A VaidyaF Civantos
Mar 21, 2001·The Journal of Urology·G DalbagniV Reuter
Mar 1, 2002·The Cochrane Database of Systematic Reviews·M D ShelleyM D Mason
Aug 20, 2004·The New England Journal of Medicine·Massimo CristofanilliDaniel F Hayes
Oct 27, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·W Jeffrey AllardLeon W M M Terstappen
Nov 7, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·G Thomas BuddDaniel F Hayes
Apr 4, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David R ShafferHoward I Scher
Dec 7, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Daniel C DanilaHoward I Scher
Jan 24, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J SastreE Díaz-Rubio
Oct 7, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D J GallagherD F Bajorin
May 29, 2009·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun

❮ Previous
Next ❯

Citations

Jan 23, 2016·Molecular Oncology·Kiki C AndreeLeon W M M Terstappen
May 15, 2012·The Journal of Urology·Alexander C SmallMatthew D Galsky
Mar 29, 2014·Epigenetics : Official Journal of the DNA Methylation Society·Scott M LangevinKarl T Kelsey
Oct 15, 2019·Expert Review of Molecular Diagnostics·Erik KoubaLiang Cheng
Aug 10, 2017·Oncology Letters·Dimple ChudasamaVladimir Anikin
Feb 1, 2018·Nature Biomedical Engineering·Mahla PoudinehShana O Kelley
Jan 23, 2018·Advanced Drug Delivery Reviews·Sabine RiethdorfKlaus Pantel
Apr 20, 2021·Clinical Oncology : a Journal of the Royal College of Radiologists·A A SolankiJ A Efstathiou

❮ Previous
Next ❯

Methods Mentioned

BETA
dissection
PCR
antibody capture

Software Mentioned

- Search System
Cell
Veridex
Cell Search System
- Search
Search System

Related Concepts

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.