Perioperative Stroke and Mortality After Surgical Aortic Valve Replacement: A Meta-Analysis

The Neurologist
Karthy ThiagarajanParthasarathy D Thirumala

Abstract

Perioperative stroke rate after surgical aortic valve replacement (SAVR) varies between 1.3% and 6.2%, whereas the operative mortality ranges between 1% and 16.4%. The aim of this study was to determine whether perioperative stroke is a risk factor for operative mortality after SAVR by performing a meta-analysis of relevant studies. PubMed, EMBASE, and Web of Science databases were searched to retrieve relevant literature. Screening of the articles was done independently on the basis of predetermined criteria. Data from the relevant studies were extracted and a random effects model was used to calculate the odds of mortality among patients with perioperative strokes after aortic valve replacement compared with those without such strokes. Subgroup analyses of patients (1) aged above and below 70 years and (2) undergoing isolated valve replacement procedure were performed. Metaregression to check for association of effect estimate and (1) sex, (2) mechanical valve replacement, (3) New York Heart Association class III/IV, (4) left ventricle ejection fraction <30%, and (5) preoperative atrial fibrillation was performed. Statistical analyses using a random effects model showed that patients with perioperative strokes had 4.74 times ...Continue Reading

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Citations

Mar 17, 2018·Anesthesia and Analgesia·Andra E Duncan
Feb 6, 2020·Journal of Clinical Laboratory Analysis·Nan XuDong Cai
Aug 5, 2020·Der Anaesthesist·M Fischer, U Kahl

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