Perioperative urinary thromboxane metabolites and outcome of coronary artery bypass grafting: a nested case-control study

BMJ Open
Hanning LiuZhe Zheng

Abstract

As a marker of in vivo thromboxane generation, high-level urinary thromboxane metabolites (TXA-M) increase the occurrence of cardiovascular events in high-risk patients. To investigate whether perioperative urinary TXA-M level is associated with major adverse cardiac and cerebrovascular events (MACCE) after coronary artery bypass graft (CABG) surgery, we designed a nested case-control study. Observational, nested case-control study. Single-centre outcomes research in Fuwai Hospital, Beijing, China. One thousand six hundred and seventy Chinese patients undergoing CABG surgery from September 2011 to October 2013. We obtained urinary samples from 1670 Chinese patients undergoing CABG 1 hour before surgery (pre-CABG), and 6 hours (post-CABG 6 hours) and 24 hours after surgery (post-CABG 24 hours). Patients were followed up for 1 year, and we observed 56 patients had MACCE. For each patient with MACCE, we matched three control subjects. Perioperative urinary TXA-M of the three time spots was detected in these 224 patients. Post-CABG 24 hours TXA-M is significantly higher than that of patients without MACCE (11 101vs8849 pg/mg creatine, P=0.007). In addition, patients in the intermediate tertile and upper tertile of post-CABG 24 hour...Continue Reading

Associated Clinical Trials

References

Sep 1, 1975·The Journal of Clinical Investigation·G J Roth, P W Majerus
May 23, 1998·Annual Review of Pharmacology and Toxicology·J R VaneR M Botting
Mar 15, 2000·Circulation·E H Awtry, J Loscalzo
Apr 20, 2002·Science·Yan ChengGarret A FitzGerald
May 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Bianca RoccaCarlo Patrono
Oct 29, 2005·The American Journal of Cardiology·Abdul R HalabiPeter K Smith
Feb 21, 2006·Lancet·Graeme J Hankey, John W Eikelboom
Oct 8, 2008·Circulation·John W EikelboomUNKNOWN Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management and Avoidance (CHARISMA) Investigators
Feb 21, 2009·The New England Journal of Medicine·Patrick W SerruysUNKNOWN SYNTAX Investigators
Mar 18, 2010·Interactive Cardiovascular and Thoracic Surgery·Hernán Cohen AraziJuan Jose Badimon
Apr 13, 2010·The International Journal of Artificial Organs·Thomas RimmeléJohn A Kellum
Jun 15, 2010·Clinical Lipidology·Emer M Smyth
Feb 26, 2011·Journal of the American College of Cardiology·Tyler J GluckmanJeffrey J Rade
Dec 20, 2013·Journal of Cardiovascular Translational Research·P FontanaJ-L Reny
Sep 4, 2015·Lancet·Raffaele PiccoloStephan Windecker
May 6, 2016·The New England Journal of Medicine·Zhe ZhengBarbara Casadei

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Methods Mentioned

BETA
coronary artery bypass

Clinical Trials Mentioned

NCT01573143

Software Mentioned

SPSS

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