Perioptic Cerebrospinal Fluid Dynamics in Idiopathic Intracranial Hypertension

Frontiers in Neurology
Achmed PircherHanspeter E Killer

Abstract

Purpose: To examine the cerebrospinal fluid (CSF) dynamics along the entire optic nerve in patients with idiopathic intracranial hypertension (IIH) and papilledema by computed tomographic (CT) cisternography. Methods: Retrospective analysis of CT cisternographies in 16 patients with a history of IIH and papilledema (14 females and 2 males, mean age: 49 ± 16 years). Contrast loaded CSF (CLCSF) was measured in Hounsfield Units (HU) at three defined regions of interest (ROI) along the optic nerve (orbital optic nerve portion: bulbar and mid-orbital segment, intracranial optic nerve portion) and additionally in the basal cistern. The density measurements in ROI 1, ROI 2, and ROI 3 consist of measurements of the optic nerve complex: optic nerve sheath, CLCSF filled SAS and optic nerve tissue. As controls served a group of patients (mean age: 60 ± 19 years) without elevated intracranial pressure and without papilledema. Results: In IIH patients the mean CLCSF density in the bulbar segment measured 65 ± 53 HU on the right and 63 ± 35 HU on the left side, in the mid-orbital segment 68 ± 37 HU right and 60 ± 21 HU left. In the intracranial optic nerve portion 303 ± 137 HU right and 323 ± 169 HU left and in the basal cistern 623 ± 188 HU...Continue Reading

References

May 1, 1979·Experimental Eye Research·S S HayrehD R Anderson
Apr 1, 1991·Archives of Neurology·J Marcelis, S D Silberstein
Jan 1, 1984·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·S S Hayreh
Jun 13, 2001·Neurology·R Huna-BaronM J Kupersmith
Nov 29, 2002·Neurology·Deborah I Friedman, Daniel M Jacobson
Nov 10, 2004·Neurology·A KeslerA D Korczyn
Mar 1, 2006·Brain : a Journal of Neurology·H E KillerA R Huber
Apr 25, 2006·Lancet Neurology·Alex K Ball, Carl E Clarke
Nov 26, 2009·Acta Neurologica Scandinavica·S DhunganaN Woodroofe
Dec 3, 2009·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Byron N Wilkes, R Michael Siatkowski
Jul 20, 2010·Neurologic Clinics·Michael Wall
May 26, 2011·PloS One·Xiaorong XinAlbert Neutzner
Mar 17, 2012·Journal of Neurology, Neurosurgery, and Psychiatry·Valérie BiousseNancy J Newman
Aug 8, 2014·Continuum : Lifelong Learning in Neurology·Deborah I Friedman
Dec 11, 2014·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Samuel BidotValérie Biousse
Oct 11, 2015·Progress in Retinal and Eye Research·Sohan Singh Hayreh
Nov 19, 2015·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Samuel BidotBeau B Bruce
Dec 22, 2015·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Inessa BekermanMichael Vaiman
Dec 9, 2016·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Thomas H MaderAndrew G Lee
Mar 11, 2017·Frontiers in Neurology·Achmed PircherHanspeter E Killer
Apr 30, 2017·American Journal of Ophthalmology·Mikee LiuganMing Zhang

❮ Previous
Next ❯

Software Mentioned

VitreaCore
Advantage Workstation
Excel
SigmaPlot

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.