Periostin accelerates bone healing mediated by human mesenchymal stem cell-embedded hydroxyapatite/tricalcium phosphate scaffold

PloS One
Soon Chul HeoJae Ho Kim

Abstract

Periostin, an extracellular matrix protein, is expressed in bone, more specifically, the periosteum and periodontal ligaments, and plays a key role in formation and metabolism of bone tissues. Human adipose tissue-derived mesenchymal stem cells (hASCs) have been reported to differentiate into osteoblasts and stimulate bone repair. However, the role of periostin in hASC-mediated bone healing has not been clarified. In the current study, we examined the effect of periostin on bone healing capacity of hASCs in a critical size calvarial defect model. Recombinant periostin protein stimulated migration, adhesion, and proliferation of hASCs in vitro. Implantation of either hASCs or periostin resulted in slight, but not significant, stimulation of bone healing, whereas co-implantation of hASCs together with periostin further potentiated bone healing. In addition, the number of Ki67-positive proliferating cells was significantly increased in calvarial defects by co-implantation of both hASCs and periostin. Consistently, proliferation of administered hASCs was stimulated by co-implantation with periostin in vivo. In addition, co-delivery of hASCs with periostin resulted in markedly increased numbers of CD31-positive endothelial cells and...Continue Reading

References

Jul 15, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K HoriuchiA Kudo
Jun 22, 2002·Nature·Yuehua JiangCatherine M Verfaillie
Feb 3, 2004·The Journal of the American Academy of Orthopaedic Surgeons·Thomas A DeCosterMiguel A Pirela-Cruz
Mar 26, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Agnieszka Kruzynska-FrejtagSimon J Conway
Jul 20, 2004·Journal of Cellular Biochemistry·Judith LitvinFayez F Safadi
Oct 20, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Florian GeigerWiltrud Richter
Jan 27, 2006·The American Journal of Pathology·Mahesh H MankaniPamela Gehron Robey
Jan 18, 2007·Journal of Cellular Biochemistry·Russell A NorrisRoger R Markwald
Jan 23, 2008·The Journal of Experimental Medicine·Masashi ShimazakiAkira Kudo
Nov 14, 2008·Journal of Cellular Physiology·Shimei ZhuJudith Litvin
May 30, 2009·Journal of Cellular Biochemistry·Kai RuanGaoliang Ouyang
Jun 23, 2010·PloS One·Benjamin LeviMichael T Longaker
Jul 2, 2010·Stem Cells and Development·Sergei A KuznetsovPamela Gehron Robey
Jun 15, 2011·Molecular Cancer Therapeutics·Min ZhuDennis J Slamon
Oct 15, 2011·Virchows Archiv : an International Journal of Pathology·Laura Morra, Holger Moch
Feb 9, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·B Merle, P Garnero
Mar 27, 2012·Stem Cells International·Elham Zomorodian, Mohamadreza Baghaban Eslaminejad
Apr 14, 2012·Circulation Journal : Official Journal of the Japanese Circulation Society·Han Cheol LeeJin Sup Jung
May 9, 2012·Current Stem Cell Research & Therapy·Nikolaos C KeramarisNicola Maffulli
Aug 29, 2012·Proceedings of the National Academy of Sciences of the United States of America·Nicolas BonnetSerge L Ferrari
Dec 1, 2012·Stem Cells Translational Medicine·Krisztina Szöke, Jan E Brinchmann
May 25, 2013·Journal of Cellular Physiology·Georgios E RomanosVijay L Deshmukh

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Citations

Jan 2, 2016·Molecular and Cellular Endocrinology·Nicolas BonnetSerge Ferrari
Feb 18, 2016·Stem Cells International·Azizeh-Mitra YousefiHassane Oudadesse
Jul 25, 2015·Journal of Cellular Physiology·Gabriele CeccarelliGabriella M Cusella De Angelis
Sep 11, 2017·Cellular and Molecular Life Sciences : CMLS·Juan Du, Minqi Li
Nov 6, 2018·Current Stem Cell Research & Therapy·Dilcele Silva Moreira DziedzicKatherine Athayde Teixeira de Carvalho
Jan 2, 2019·Biomaterials Research·Seong Gyu KwonJae Ho Kim
Jul 9, 2020·Tissue Engineering. Part B, Reviews·Maximilian M MengerTina Histing
Aug 28, 2021·Materials·Vivian Alonso-GoulartLetícia de Souza Castro-Filice

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