Periostin is essential for cardiac healing after acute myocardial infarction.

The Journal of Experimental Medicine
Masashi ShimazakiAkira Kudo

Abstract

Acute myocardial infarction (AMI) is a common and lethal heart disease, and the recruitment of fibroblastic cells to the infarct region is essential for the cardiac healing process. Although stiffness of the extracellular matrix in the infarct myocardium is associated with cardiac healing, the molecular mechanism of cardiac healing is not fully understood. We show that periostin, which is a matricellular protein, is important for the cardiac healing process after AMI. The expression of periostin protein was abundant in the infarct border of human and mouse hearts with AMI. We generated periostin(-/-) mice and found no morphologically abnormal cardiomyocyte phenotypes; however, after AMI, cardiac healing was impaired in these mice, resulting in cardiac rupture as a consequence of reduced myocardial stiffness caused by a reduced number of alpha smooth muscle actin-positive cells, impaired collagen fibril formation, and decreased phosphorylation of FAK. These phenotypes were rescued by gene transfer of a spliced form of periostin. Moreover, the inhibition of FAK or alphav-integrin, which blocked the periostin-promoted cell migration, revealed that alphav-integrin, FAK, and Akt are involved in periostin signaling. Our novel finding...Continue Reading

References

Feb 6, 1996·Biochemical and Biophysical Research Communications·K UrasawaA Kitabatake
Jul 15, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K HoriuchiA Kudo
Apr 25, 2000·Cardiovascular Research·Y Sun, K T Weber
May 16, 2000·Circulation Research·L W StantonR T White
Sep 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·H B WangY Wang
May 4, 2002·Nature Reviews. Molecular Cell Biology·James J TomasekRobert A Brown
Apr 4, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Satoshi AraiAkira Kudo
Oct 23, 2003·Annual Review of Cell and Developmental Biology·Alexander D BershadskyBenjamin Geiger
Nov 25, 2003·The American Journal of Pathology·Jitka Ismail Virag, Charles E Murry
Sep 24, 2004·Circulation·Naruto KatsuragiKeijiro Sugimura
Oct 30, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Volkhard LindnerCalvin P H Vary
Feb 3, 2005·Nature Reviews. Molecular Cell Biology·Satyajit K MitraDavid D Schlaepfer
Feb 16, 2005·The Journal of Clinical Investigation·Shin-ichiro MatsumuraYasunori Okada
Mar 26, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Yukihiko MomiyamaFumitaka Ohsuzu
May 11, 2005·Biochemical and Biophysical Research Communications·Hideyo UgaiKazunari K Yokoyama
May 24, 2005·Gene Expression Patterns : GEP·Andrew LindsleySimon J Conway
Sep 15, 2005·The Journal of Biological Chemistry·Daihiko HakunoRichard T Lee
Feb 25, 2006·Biochemical and Biophysical Research Communications·Isao KiiAkira Kudo
Mar 2, 2006·The British Journal of Psychiatry : the Journal of Mental Science·G Critchlow, H Nadeem
Mar 15, 2006·Cardiovascular Research·Hidenori MatsusakaHiroyuki Tsutsui
Apr 18, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Troy A BaudinoThomas K Borg
Jul 28, 2006·Trends in Cell Biology·Vuk Stambolic, James R Woodgett
Nov 18, 2006·Cardiovascular Research·Marcin Bujak, Nikolaos G Frangogiannis
Jan 18, 2007·Journal of Cellular Biochemistry·Russell A NorrisRoger R Markwald
Mar 3, 2007·The Journal of Clinical Investigation·Bradford C BerkStephanie Lehoux

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Citations

Aug 13, 2011·Cellular and Molecular Life Sciences : CMLS·Akira Kudo
Jan 10, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Tibor KempfKai C Wollert
Sep 9, 2011·Development Genes and Evolution·Si TaoSusanne J Kühl
Aug 26, 2011·Journal of Cardiovascular Translational Research·Daihiko HakunoKeiichi Fukuda
Aug 11, 2012·Journal of Cardiovascular Translational Research·Jacquelyn D Lajiness, Simon J Conway
Aug 29, 2012·Journal of Cardiovascular Translational Research·Yonggang MaMerry L Lindsey
Jul 29, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·K BoltonK Walder
Jun 20, 2012·Proceedings of the National Academy of Sciences of the United States of America·Angela LortsJeffery D Molkentin
Feb 26, 2010·The Journal of Biological Chemistry·Takumi MaruhashiAkira Kudo
Oct 16, 2009·Cardiology in Review·David C SaneRichard C Becker
Nov 24, 2012·American Journal of Physiology. Cell Physiology·Edie C GoldsmithFrancis G Spinale
Mar 23, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Yuan-Wen ChenLouis J Dell'italia
Jul 12, 2011·Physiological Reviews·Mark A SussmanMichael McGregor
Apr 9, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·James E HixsonDavid Herrington
Jun 21, 2008·Circulation Research·Marc S Penn, Abeel A Mangi
Nov 7, 2009·Circulation Research·Paige SniderSimon J Conway
Sep 3, 2010·The Journal of Clinical Investigation·Polakit TeekakirikulJonathan G Seidman
Jun 12, 2012·The Journal of Clinical Investigation·Miho MasuokaKenji Izuhara
Jun 11, 2010·BMC Cancer·Verena TischlerGlen Kristiansen
Jan 24, 2012·Journal of Cell Science·Christopher G ElliottDouglas W Hamilton
Jul 30, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Masanori Asakura, Masafumi Kitakaze
Apr 30, 2008·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Yoshinao KikuchiMasashi Fukayama
Oct 8, 2013·PloS One·Marcos F MinicucciLeonardo A M Zornoff
Nov 22, 2013·PloS One·Osamu YamashitaKimikazu Hamano
Dec 19, 2013·PloS One·Luciana K Rosselli-MuraiRogerio M Castilho
Mar 9, 2012·Vascular Health and Risk Management·Jane Hoover-Plow, Yanqing Gong
May 5, 2011·World Journal of Biological Chemistry·Yutaka MatsuiToshimitsu Uede

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Methods Mentioned

BETA
flow cytometry
electron microscopy

Software Mentioned

Image J

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