Peripartum maternal and foetal ghrelin, growth hormones, IGFs and insulin interrelations

Clinical Endocrinology
Jens FuglsangPer Ovesen

Abstract

Ghrelin may influence GH secretion and is associated with insulin sensitivity. In pregnancy, placental growth hormone (PGH) replaces GH. The aim of this study was to investigate the relationship between PGH and ghrelin and their relationship to insulin sensitivity in pregnancy. Prospective, descriptive study. Thirty-seven singleton pregnant and six twin pregnant women Maternal blood samples were drawn before and 2 days after elective caesarian section (CS). Serum total ghrelin, PGH, GH, GH-binding protein, insulin and IGF-I and IGF-II, and plasma glucose were determined. Insulin sensitivity indices (ISIs) were calculated. Cord blood samples were drawn at delivery for ghrelin determination. Serum ghrelin only displayed a minimal, although statistically significant, decrease after CS. Prior to delivery serum PGH increased by 25% during fasting, and was undetectable the day after CS. Serum levels of GH were low until 48 h after CS. No significant correlations were detected between PGH or ghrelin and ISIs, although a trend was observed for ghrelin. Twin pregnancies had higher PGH levels than singletons; however, levels of IGFs were similar. In cord blood, ghrelin levels were higher in arterial than venous samples. Maternal ghrelin ...Continue Reading

References

Jan 11, 1992·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·L StefaneanuL Jin
Aug 1, 1989·British Journal of Obstetrics and Gynaecology·L ErikssonB Von Schoultz
Jan 1, 1988·Acta Obstetricia Et Gynecologica Scandinavica·L ErikssonB von Schoultz
Jun 1, 1988·The Journal of Clinical Endocrinology and Metabolism·F FrankenneG Hennen
Jul 1, 1994·Proceedings of the Society for Experimental Biology and Medicine·G Massa
Apr 8, 2000·European Journal of Endocrinology·C L BoguszewskiL M Carlsson
Apr 11, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·N NagayaK Kangawa
Mar 19, 2002·Hypertension·Yasuo MakinoTatsuhiko Kawarabayashi
Mar 21, 2002·American Journal of Obstetrics and Gynecology·Linda A BarbourJacob E Friedman
Sep 28, 2002·Journal of Pediatric Gastroenterology and Nutrition·Jean-Pierre ChanoineCarl Laird Birmingham
Feb 8, 2003·The Journal of Clinical Endocrinology and Metabolism·Zida WuChristian J Strasburger
Feb 8, 2003·The Journal of Clinical Endocrinology and Metabolism·Niels MøllerK Sreekumaran Nair
Jul 31, 2003·European Journal of Endocrinology·Donatella CortelazziAnna Spada
Sep 13, 2003·The Journal of Clinical Endocrinology and Metabolism·Juliet FarquharJean-Pierre Chanoine
Oct 15, 2003·The Journal of Clinical Endocrinology and Metabolism·Jens FuglsangPer Ovesen
Nov 7, 2003·The Journal of Clinical Endocrinology and Metabolism·Seiko KitamuraYasuhiro Kuroda
Mar 12, 2004·European Journal of Endocrinology·N Wierup, F Sundler
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·F BroglioE Ghigo
Jun 9, 2004·Frontiers in Neuroendocrinology·Márta KorbonitsAshley B Grossman
Jan 11, 2005·Clinical Endocrinology·E GhigoG Muccioli
Apr 28, 2005·Clinical Endocrinology·Jens FuglsangPer Ovesen

❮ Previous
Next ❯

Citations

Sep 11, 2010·Archives of Gynecology and Obstetrics·Filiz SaylanMehmet Yılmazer
Dec 7, 2011·European Journal of Endocrinology·Hamilcikan SahinYildiz Perk
Nov 3, 2009·Diabetes Care·H David McIntyreUNKNOWN Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study Cooperative Research Group
Mar 26, 2010·Pakistan Journal of Biological Sciences : PJBS·Safaa S ImamR Bahier
Apr 13, 2010·European Journal of Endocrinology·Jens FuglsangPer Ovesen
Aug 28, 2010·International Journal of Peptides·Johannes D Veldhuis, Cyril Y Bowers
Apr 19, 2008·Clinical Endocrinology·Francisco Méndez-RamírezJuan Manuel Malacara
Sep 19, 2007·Journal of Internal Medicine·M RiedlA Kautzky-Willer
Jan 5, 2013·Clinical Endocrinology·Mireille N M van PoppelGernot Desoye
Jun 28, 2007·The Journal of Clinical Endocrinology and Metabolism·Susan Riddle BrianSilvio E Inzucchi
Sep 30, 2010·Scandinavian Journal of Clinical and Laboratory Investigation·Mikkel AndreassenLars Ø Kristensen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.