Abstract
Patients with peripheral artery disease show an exaggerated pressor response to mild exercise, an effect attributable to the exercise pressor reflex, whose afferent arm comprises the thinly myelinated group III and unmyelinated group IV afferents. Previously, we found that DAMGO, a µ-opioid agonist injected into the femoral artery, attenuated the exaggerated exercise pressor reflex in rats with ligated femoral arteries, a preparation that simulates the blood flow patterns to muscle that is seen in patients with peripheral artery disease. Continuing this line of investigation, we recorded the responses of group III and IV afferents to static contraction before and after injecting DAMGO (1 µg) into the superficial epigastric artery in rats with patent femoral arteries and in rats with ligated femoral arteries. In rats with patent arteries, DAMGO did not change the responses to contraction of either group III ( n = 9; P = 0.83) or group IV ( n = 8; P = 0.34) afferents. In contrast, in rats with ligated femoral arteries, DAMGO injection (1 µg) significantly decreased the responses to contraction of both group III afferents ( n = 9, P < 0.01) and group IV afferents ( n = 9; P < 0.01). DAMGO did not significantly attenuate the respon...Continue Reading
References
Apr 1, 1991·The Journal of Physiology·S N Lawson, P J Waddell
Jun 1, 1990·Journal of Applied Physiology·J M Hill, M P Kaufman
Jan 1, 1989·Neuroscience·P J WaddellP W McCarthy
Sep 3, 1986·Brain Research·G PomeroyR D Wurster
Jul 1, 1972·The Journal of Physiology·D I McCloskey, J H Mitchell
Jul 1, 1971·The Journal of Physiology·J H CooteJ F Perez-Gonzalez
Jul 1, 1983·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·M P KaufmanJ H Mitchell
Jan 1, 1982·Circulation Research·M P KaufmanJ H Mitchell
Jan 1, 1993·Experimental Brain Research·B DiehlS Mense
Aug 1, 1997·Brain Research·R E CoggeshallS M Carlton
May 29, 1999·Angiology·G BaccelliM Catalano
Feb 5, 2003·Neuroscience Letters·Jochen ReinöhlSiegfried Mense
Jul 24, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Barry M PriorRonald L Terjung
Aug 29, 2006·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·E F BakkeE Stranden
Jan 26, 2008·The Journal of Physiology·Jessica C TaylorRonald L Terjung
Apr 27, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Hirotsugu TsuchimochiMarc P Kaufman
Jun 15, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Hirotsugu TsuchimochiMarc P Kaufman
Jul 17, 2010·Journal of Applied Physiology·Markus AmannJerome A Dempsey
Oct 19, 2011·The Journal of Physiology·Hirotsugu TsuchimochiMarc P Kaufman
Sep 26, 2012·The Journal of Physiology·Matthew D MullerLawrence I Sinoway
Apr 10, 2013·The Journal of Physiology·Katsuya YamauchiMarc P Kaufman
Sep 19, 2014·Journal of Neurophysiology·Bassil HassanVictor Ruiz-Velasco
Oct 19, 2017·Neuropharmacology·Wenling ChenJuan Carlos Marvizón
Jan 18, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Juan A Estrada, Marc P Kaufman
Citations
Apr 4, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Joyce S Kim, Marc P Kaufman
Jun 24, 2020·Peptides·Richard J Bodnar
Oct 2, 2021·European Journal of Applied Physiology·Luca AngiusSamuele Maria Marcora