Peripheral 5-HT2A receptor antagonism attenuates primary thermal hyperalgesia and secondary mechanical allodynia after thermal injury in rats

Pain
Masayuki SasakiFumio Goto

Abstract

Inflammation or injury of peripheral tissue causes release of chemical mediators, including 5-hydroxytryptamine (5-HT), which is involved in the facilitation of nociceptive transmission and the induction of hyperalgesia. The present study examined the effect of a selective 5-HT2A receptor antagonist, sarpogrelate, on hyperalgesia and allodynia induced by thermal injury in rats. Mild thermal injury to the hindpaw produces thermal hyperalgesia in the injured area (primary thermal hyperalgesia) and mechanical allodynia in sites adjacent to the primary area (secondary mechanical allodynia). Mechanical allodynia was assessed by paw withdrawal thresholds using von Frey filaments, and thermal hyperalgesia was assessed by paw withdrawal latencies upon exposure to a radiant heat source. Intraperitoneal administration (30-100 mg/kg) or local injection (30-300 microg) of sarpogrelate 10 min prior to thermal injury attenuated secondary mechanical allodynia in a dose-dependent manner. Intraperitoneal administration (3-100 mg/kg) or local injection (30-300 microg) of sarpogrelate 10 min prior to thermal injury attenuated primary thermal hyperalgesia in a dose-dependent manner. Intraplantar injection of sarpogrelate (300 microg) to the contra...Continue Reading

References

Jan 1, 1992·Pharmacology, Biochemistry, and Behavior·K J SufkaJ Giordano
Jan 1, 1992·Neuroscience·Y O Taiwo, J D Levine
Jan 1, 1992·Progress in Neurobiology·R D TreedeJ N Campbell
Apr 1, 1991·Journal of Pharmacobio-dynamics·K MaruyamaT Nagatomo
Oct 24, 1989·European Journal of Pharmacology·J Giordano, L V Rogers
Jan 1, 1989·Immunopharmacology·C P Page
Jan 14, 1982·Brain Research·J G Thalhammer, R H LaMotte
Jul 1, 1994·Journal of Neuroscience Methods·S R ChaplanT L Yaksh
Oct 21, 1998·Neuroscience Letters·N Nozaki-Taguchi, T L Yaksh
May 12, 2001·The Breast Journal·Mary E. LobranoArthur W. Zieske
Jul 20, 2001·British Journal of Anaesthesia·B L Kidd, L A Urban
Jun 25, 2003·European Journal of Pain : EJP·Fernando CerveroEsther García-Nicas
May 27, 2005·European Journal of Pharmacology·Tomoki Nishiyama

❮ Previous
Next ❯

Citations

Nov 2, 2007·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Miho SekiguchiShin-ichi Kikuchi
Oct 1, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Kirsty BannisterAnthony H Dickenson
May 8, 2007·The Journal of Pharmacology and Experimental Therapeutics·Xi-Chun ZhangDan Levy
Nov 3, 2010·The Journal of Clinical Investigation·Michael H OssipovFrank Porreca
May 24, 2008·Anesthesia and Analgesia·Feikje WesseldijkFreek J Zijlstra
Nov 17, 2011·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C H SantuzziG R Abreu
Jan 1, 2012·Scientifica·Michael H Ossipov
Sep 25, 2012·Seminars in Cell & Developmental Biology·Dayna R LoydKenneth M Hargreaves
Jun 12, 2012·Pharmacology, Biochemistry, and Behavior·Maria Cláudia G Oliveira-FusaroCláudia Herrera Tambeli
Feb 15, 2008·The Journal of Comparative Neurology·João Manuel Braz, Allan I Basbaum
Mar 9, 2013·BJU International·Kenneth R Turley, David L Rowland
Mar 18, 2016·Pain Management·Milena De Felice, Michael H Ossipov
Feb 1, 2012·Pharmacology, Biochemistry, and Behavior·Mariana Bravo-HernándezVinicio Granados-Soto
Jun 28, 2011·Pharmacology, Biochemistry, and Behavior·Elias B NascimentoMárcio M Coelho
Apr 6, 2012·Pharmacology, Biochemistry, and Behavior·Claudia Cervantes-DuránVinicio Granados-Soto
Mar 19, 2013·European Journal of Pharmacology·Florent ViguierSylvie Bourgoin
Apr 23, 2014·Current Opinion in Supportive and Palliative Care·Michael H OssipovFrank Porreca
Aug 21, 2018·European Journal of Pain : EJP·Catherine E FerlandJean A Ouellet
Nov 17, 2019·International Journal of Molecular Sciences·Stephania ParedesNebojsa Nick Knezevic
Oct 24, 2017·Mediators of Inflammation·Audrey Ortega-RamírezEnrique Soto
Oct 17, 2017·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Michael MorganIrina Vetter
Apr 17, 2021·Laboratory Investigation; a Journal of Technical Methods and Pathology·Jeffri S RetamalPeter McIntyre

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.