Peripheral administration of human corticotropin-releasing hormone: a novel method to increase energy expenditure and fat oxidation in man

The Journal of Clinical Endocrinology and Metabolism
S R SmithG A Bray

Abstract

CRH increases energy expenditure and decreases food intake in experimental animals. We proposed the hypothesis that peripheral administration of CRH might increase energy expenditure in human subjects. Four men and four women (age, 19-39 yr) were randomized to a double blind, cross-over trial to test the effect of human CRH (hCRH), ovine CRH (oCRH), and placebo on resting energy expenditure measured by indirect calorimetry. CRH was administered by primed continuous infusion at progressively increasing doses of 0.5, 1.0, and 2.0 microg/kg.h at 2-h intervals. hCRH increased resting energy expenditure by 13.9% at the end of the infusion. Respiratory quotient fell from 0.828 to 0.768 during the hCRH infusion compared with a fall from 0.836 to 0.807 during placebo infusion (P < 0.05). Fat oxidation increased by 55% compared with placebo at the highest dose of hCRH. Heart rate increased during hCRH to 10.7 bpm higher than placebo (P < 0.05). oCRH did not increase heart rate. oCRH also had no significant effect on respiratory quotient, and only a small effect on energy expenditure. During hCRH infusion, venous plasma epinephrine, norepinephrine, glycerol, and nonesterified fatty acid levels were not significantly different from those ...Continue Reading

Citations

Mar 20, 2003·Current Diabetes Reports·Steven R Smith, Eric Ravussin
Apr 13, 2010·Hormones and Behavior·Alfonso Abizaid
Feb 16, 2008·Physiology & Behavior·Arie G Nieuwenhuizen, Femke Rutters
May 9, 2012·Biological Reviews of the Cambridge Philosophical Society·Steven W GangestadMelissa A Eaton
Nov 29, 2005·Trends in Endocrinology and Metabolism : TEM·Johannes KleinMathias Fasshauer
Sep 29, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·P WellhönerC Dodt
Dec 14, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·L HeilbronnE Ravussin

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