PMID: 11311727Apr 20, 2001Paper

Peripheral administration of urocortin suppresses operant responding for food reward

Peptides
J W KinneyD D Avery

Abstract

The effects of peripheral systemic administration of urocortin on operant responding to obtain food were investigated using three separate concentrations. The drug was administered intraparitoneally at a concentration of 10 microg/ml/Kg, 5 microg/ml/Kg, and 0 microg/ml/Kg suspended in saline at a volume of 1 ml/Kg to Sprague-Dawley rats fifteen minutes prior to being exposed to an operant bar press task. Eleven subjects were used, each receiving a single injection of each concentration on separate days with the order of treatment counterbalanced. The results indicated that the administration of urocortin in a dose dependent manner reduced responding of food deprived subjects for a food reward in a thirty minute session. These data indicated that the peripheral administration of urocortin reduced the motivation of food deprived subjects to respond.

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Citations

Nov 7, 2006·Frontiers in Neuroendocrinology·Eva M Fekete, Eric P Zorrilla
Dec 15, 2007·Progress in Neurobiology·Weihong Pan, Abba J Kastin
Jul 1, 2008·British Journal of Pharmacology·X LiS Li
Jul 27, 2014·Journal of Physiology and Biochemistry·Ahmed A El-Gendy, Amr M Abbas
Mar 29, 2011·Stress : the International Journal on the Biology of Stress·Tamás KoziczLu Xu
Oct 20, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·L WangY Taché

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