Peripheral afferent stimulation of decentralized sympathetic neurons activates lipolysis in spinal cord-injured subjects

Metabolism: Clinical and Experimental
A K KarlssonP Lönnroth

Abstract

Spinal cord-injured (SCI) subjects exhibit a normal lipolytic rate despite the failure of centrally mediated sympathoexcitatory stimuli to activate lipolysis. Peripheral afferent stimulation below the lesion level induces an exaggerated autonomic reaction in SCI with lesion levels above T5, ie, so-called autonomic dysreflexia. The metabolic effects of induced dysreflexia were investigated in five SCI subjects (age, 35 +/- 8 years; duration of paresis, 15 +/- 7.5 years [mean +/- SD]; lesion level, T3 to T4, n = 2, C7, n = 3) following bladder stimulation. Subcutaneous glycerol concentrations were measured by microdialysis above and below the lesion level. Diurnal plasma noradrenaline (NA) and adrenaline levels were continuously monitored in seven SCI subjects (lesion level T3 to T4, n = 2; C4 to C7, n = 5). Bladder stimulation resulted in an increased mean arterial pressure ([MAP] 81 +/- 8 to 114 +/- 11 mm Hg, P < .05), a decreased heart rate (70 +/- 3 to 54 +/- 4 beats/min, P < .05), and an increased plasma NA (0.70 +/- 0.49 v 3.27 +/- 1.56 nmol/L, P < .05). Interstitial glycerol was increased in the decentralized region (89 +/- 12 to 135 +/- 21 mumol/L, P < .05), whereas no reaction was found in the centrally innervated region...Continue Reading

Citations

May 20, 2009·Neurorehabilitation and Neural Repair·Angela S LairdPhil M E Waite
Sep 24, 2009·Journal of Neurotrauma·Jessica InskipAndrei Krassioukov
May 17, 2011·PM & R : the Journal of Injury, Function, and Rehabilitation·Ashraf S Gorgey, David R Gater
Aug 23, 2017·PM & R : the Journal of Injury, Function, and Rehabilitation·Ashraf S GorgeyDavid R Gater
Jun 21, 2007·Spinal Cord·G-M Bennegard, A-K Karlsson
Oct 24, 2015·PM & R : the Journal of Injury, Function, and Rehabilitation·Ashraf S Gorgey, Justin Lawrence
Feb 18, 2011·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Ashraf S Gorgey, David R Gater
Feb 12, 2020·The Journal of Spinal Cord Medicine·Maria PollifroneRita Hamilton

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