PMID: 3764311Jan 1, 1986Paper

Peripheral and central nervous system lesions caused by triethyl- and trimethyltin salts in rats

Toxicologic Pathology
D J O'Shaughnessy, G J Losos

Abstract

Both trimethyltin and triethyltin salts are known to produce toxic lesions in the central nervous system. Triethyltin intoxication has been associated with central intramyelin edema, while trimethyltin has been shown to produce neuronal necrosis in selected limbic and sensory regions of the brain. Only scant attention has been paid to peripheral nerves of animals treated with alkyltins. In this study, we have treated rats with 6 or 8 mg/kg trimethyltin, and 1, 2, 4, 6, or 8 mg/kg triethyltin (single or multiple exposure), and evaluated in detail at the light microscope level both central and peripheral nervous system lesions. In addition to the central neuron necrosis or myelin edema described previously, both compounds produced peripheral axon degeneration and chromatolysis of large spinal cord and brain stem neurons. Chromatolysis was seen in reticular neurons of the brain stem and ventral horn or spinal cord in rats receiving high doses (6 or 8 mg/kg) of triethyltin, and in these same areas plus mesencephalic trigeminal nucleus in animals treated with trimethyltin. Wallerian-like degeneration of peripheral axons was seen in sciatic and tibial nerve and ventral roots of animals receiving 3 injections of 4 mg/kg or single or m...Continue Reading

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Citations

Mar 1, 1993·Journal of Applied Toxicology : JAT·F GagnaireJ de Ceaurriz
Oct 1, 1998·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M Nordin-AnderssonE Walum
Oct 15, 2014·Journal of Neurotrauma·Junxiang WenWise Young
Dec 1, 1989·Toxicology and Applied Pharmacology·B BroxupP Beyrouty

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