Peripheral and central neurochemical effects of the selective serotonin reuptake inhibitors (SSRIs) in humans and nonhuman primates: assessing bioeffect and mechanisms of action

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
George M Anderson

Abstract

It is clear that selective serotonin reuptake inhibitors (SSRIs) act powerfully to inhibit serotonin (5-hydroxytryptamine, 5-HT) uptake centrally and peripherally. However, there are a number of critical unanswered questions concerning the effects of the drugs in adults and children. The influence of age and duration of treatment on the extent of uptake inhibition and on the enhancement of central serotonergic functioning are unclear. In addition, the relationship of these factors and effects to the therapeutic and adverse effects of the SSRIs remain to be clarified. The general clinical utility of platelet 5-HT measurement is reviewed and studies assessing central and peripheral uptake blockade in infants and children and non-human primates are discussed. Recent investigations of central neurochemical effects of the SSRIs in primates assessed through measurement of 5-HT and related compounds in cisternal cerebrospinal fluid (CSF) of the rhesus monkey are presented. In summary, the studies described have found that: human fetal exposure to SSRIs has substantial effects on 5-HT transport in utero; exposure to SSRIs through breastmilk of mothers treated for postpartum depression usually has negligible effects on 5-HT uptake; pres...Continue Reading

References

Apr 1, 1978·Clinical Pharmacology and Therapeutics·L LembergerD Wong
Jan 1, 1992·Methods in Enzymology·G Rudnick, C J Humphreys
Sep 11, 1991·Journal of the American Academy of Child and Adolescent Psychiatry·R W Fuller, C M Beasley
Mar 1, 1991·Journal of the American Academy of Child and Adolescent Psychiatry·R A KingL Scahill
Jan 1, 1990·Annals of the New York Academy of Sciences·R W Fuller, D T Wong
Feb 1, 1990·The American Journal of Psychiatry·M H TeicherJ O Cole
Jan 1, 1990·Life Sciences·G M AndersonD J Cohen
Jan 1, 1989·Psychopharmacology·S N YoungP Finn
Oct 12, 1987·Life Sciences·G M AndersonD J Cohen
Aug 1, 1995·Proceedings of the National Academy of Sciences of the United States of America·J R Moiseiwitsch, J M Lauder
May 1, 1994·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·F KaregeJ M Gaillard
Jul 1, 1994·Trends in Pharmacological Sciences·P Blier, C de Montigny
Aug 1, 1994·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·C V VorheesJ Buelke-Sam
Mar 1, 1994·International Clinical Psychopharmacology·J Hyttel
Jan 1, 1996·Behavioural Brain Research·P M Whitaker-AzmitiaJ M Lauder
Apr 17, 1997·The New England Journal of Medicine·C N EppersonC J McDougle
Apr 1, 1997·Brain Research. Molecular Brain Research·J F PadburyG Rudnick
Feb 24, 1998·Journal of Clinical Psychopharmacology·M NarayanJ C Nelson
Mar 24, 1998·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·E S GershonS D Detera-Wadleigh
Apr 16, 1998·European Journal of Pharmacology·M TatsumiE Richelson
Aug 7, 1998·Biological Psychiatry·I Lucki
Aug 11, 1999·Trends in Neurosciences·M A Bunin, R M Wightman
Sep 4, 1999·Brain, Behavior and Evolution·L A FairbanksJ J Mann
Jun 30, 2001·The American Journal of Psychiatry·V K BurtE Muntean
Oct 2, 2001·The American Journal of Psychiatry·N EppersonG M Anderson
Oct 9, 2001·American Journal of Human Genetics·C OberM S McPeek
Nov 13, 2001·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·K P Lesch
Dec 26, 2001·Brain Research Bulletin·P M Whitaker-Azmitia
Feb 13, 2002·Biological Psychiatry·Erik J MulderRuud B Minderaa
Mar 29, 2002·Pediatric Research·Tim F OberlanderKenneth Wayne Riggs

❮ Previous
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Citations

Feb 7, 2007·Psychopharmacology·Lacramioara Spetie, L Eugene Arnold
Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Scott L LetendreUNKNOWN CHARTER Group
Feb 25, 2005·The New England Journal of Medicine·Stefan P Kruszewski
Oct 26, 2011·Proceedings of the National Academy of Sciences of the United States of America·Kimberly L SimpsonRick C S Lin
Mar 15, 2008·The Journal of Biological Chemistry·Karen L MurphyMarc G Caron
Sep 30, 2005·Journal of Child and Adolescent Psychopharmacology·Thomas GüntherKerstin Konrad
Apr 5, 2014·Psychopharmacology·Mari S Golub, Casey E Hogrefe
Aug 21, 2013·Autism Research : Official Journal of the International Society for Autism Research·Tal Levin-DecaniniSuma Jacob
Apr 18, 2006·Biological Psychiatry·Nicolas RamozJoseph D Buxbaum
Jul 18, 2006·European Urology·François Giuliano, Pierre Clément
Jul 15, 2005·Journal of Perinatology : Official Journal of the California Perinatal Association·Keri A LattimoreDelia M Vazquez
Oct 26, 2005·Developmental Science·Krista Casler, Deborah Kelemen
Apr 3, 2019·International Journal of Audiology·Grace Kellee NixonDani Tomlin
Dec 7, 2019·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Csilla EgriGabriella Ana Horvath
Dec 1, 2020·Frontiers in Behavioral Neuroscience·Courtney Rivet-Noor, Alban Gaultier
Aug 8, 2021·International Journal of Molecular Sciences·Anna TkachevPhilipp Khaitovich

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