Peripheral and central signals in the control of eating in normal, obese and binge-eating human subjects

The British Journal of Nutrition
Per M HellströmMartin R Yeomans

Abstract

The worldwide increase in the incidence of obesity is a consequence of a positive energy balance, with energy intake exceeding expenditure. The signalling systems that underlie appetite control are complex, and the present review highlights our current understanding of key components of these systems. The pattern of eating in obesity ranges from over-eating associated with binge-eating disorder to the absence of binge-eating. The present review also examines evidence of defects in signalling that differentiate these sub-types. The signalling network underlying hunger, satiety and metabolic status includes the hormonal signals leptin and insulin from energy stores, and cholecystokinin, glucagon-like peptide-1, ghrelin and peptide YY3-36 from the gastrointestinal tract, as well as neuronal influences via the vagus nerve from the digestive tract. This information is routed to specific nuclei of the hypothalamus and brain stem, such as the arcuate nucleus and the solitary tract nucleus respectively, which in turn activate distinct neuronal networks. Of the numerous neuropeptides in the brain, neuropeptide Y, agouti gene-related peptide and orexin stimulate appetite, while melanocortins and alpha-melanocortin-stimulating hormone are...Continue Reading

Associated Clinical Trials

Mar 13, 2012·Dr. Allan Geliebter

References

Oct 1, 1992·The American Journal of Clinical Nutrition·A GeliebterS A Hashim
Feb 1, 1992·The American Journal of Clinical Nutrition·R E Brolin
Sep 15, 1988·The New England Journal of Medicine·T D Geracioti, R A Liddle
Aug 19, 1985·Brain Research·J E MorleyJ Kneip
Feb 1, 1981·The American Journal of Clinical Nutrition·H R KissileffG P Smith
Nov 10, 1995·The Journal of Biological Chemistry·P E SchererH F Lodish
Jan 1, 1994·Nutrition Reviews·N ReadK Cunningham
Apr 1, 1993·Digestive Diseases and Sciences·A WettergrenJ J Holst
May 3, 1996·The Journal of Biological Chemistry·E HuB M Spiegelman
Nov 1, 1995·Addictive Behaviors·S Z Yanovski
Jan 1, 1997·Annual Review of Physiology·J J Holst
Mar 1, 1994·Harvard Review of Psychiatry·M de ZwaanR L Spitzer
Mar 21, 1998·The Journal of Clinical Investigation·A FlintJ J Holst
May 20, 1998·Digestive Diseases and Sciences·E NäslundP M Hellström
Jun 20, 1998·Science·J O Hill, J C Peters
Sep 12, 1998·The American Journal of Clinical Nutrition·E NäslundP M Hellström
Oct 1, 1998·Scandinavian Journal of Gastroenterology·M WøjdemannJ J Holst
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·C BrobergerT Hökfelt
Apr 7, 1999·The International Journal of Eating Disorders·G F AdamiN Scopinaro
Apr 8, 1999·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·E NäslundP M Hellström
Apr 9, 1999·Nature Neuroscience·T M HahnM W Schwartz
Nov 5, 1999·JAMA : the Journal of the American Medical Association·S B HeymsfieldM McCamish

❮ Previous
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Citations

Jul 12, 2007·Annals of Nutrition & Metabolism·Charlotte HoybyePer M Hellstrom
Dec 23, 2011·Perspectives in Psychiatric Care·Sandy Hannon-Engel
Jun 26, 2012·International Review of Psychiatry·Ann O Scheimann
Apr 9, 2015·The British Journal of Nutrition·Theertham Pradyumna RaoKazuo Wakabayashi
May 14, 2020·The International Journal of Eating Disorders·Zoé van DyckClaus Vögele
Sep 24, 2004·The British Journal of Nutrition·Martin R YeomansMicah Leshem
May 4, 2005·The Journal of Nutrition·Allan GeliebterSami A Hashim
May 13, 2008·The American Journal of Clinical Nutrition·Supornpim ChearskulAdamandia Kriketos
Jul 11, 2019·Metabolic Syndrome and Related Disorders·Arthur M LeeMark D DeBoer
May 23, 2020·The Journal of Clinical Endocrinology and Metabolism·Hellas CenaRossella E Nappi
Oct 6, 2006·Obesity·Gabriele V RonnettYajun Tu
May 26, 2006·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Caterina ProtoAntonio Lanzone
Jul 9, 2008·Journal of Enzyme Inhibition and Medicinal Chemistry·Xiang WeiHai-Meng Zhou
Jun 15, 2006·The Journal of Clinical Endocrinology and Metabolism·F LevinE Näslund
Jul 9, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C MartinsH Truby
Mar 1, 2008·Nature Reviews. Drug Discovery·Gareth J Sanger, Kevin Lee
Nov 8, 2013·Journal of Neurogastroenterology and Motility·Jing ZhangJiande D Z Chen
Jul 1, 2008·American Journal of Lifestyle Medicine·Allan GeliebterRoni Aviram-Friedman
May 20, 2020·Archives of Physiology and Biochemistry·Halil İbrahim Ceylan, Özcan Saygın
Oct 7, 2006·The American Journal of Clinical Nutrition·Margaret C MirchJack A Yanovski
Feb 1, 2008·The Proceedings of the Nutrition Society·Catia MartinsLinda M Morgan
Aug 8, 2015·Journal of the American College of Nutrition·Wasantha P JayawardeneDavid K Lohrmann
Aug 25, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·I R AslanC Vaisse
Nov 16, 2013·The British Journal of Nutrition·Martin R YeomansLucy Chambers
May 28, 2019·Chemical Senses·Sean M CrossonSergei Zolotukhin
Nov 30, 2020·The Journal of Nutritional Biochemistry·Sergio Montserrat-de la PazVictor Sánchez-Margalet
Jun 10, 2020·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Immacolata C NettorePaolo E Macchia
Jun 20, 2006·Best Practice & Research. Clinical Gastroenterology·G Karamanolis, J Tack
Dec 1, 2009·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Simona Perboni, Akio Inui

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