Peripheral and placental biomarkers in women with placental malaria: a systematic review

Biomarkers in Medicine
Esmée RuizendaalPetra F Mens

Abstract

Placental malaria (PM) causes significant morbidity in mothers and infants. Diagnosis of PM during pregnancy is however problematic due to placental sequestration of parasites. Host biomarkers may therefore be used as a diagnostic method. In this systematic review most studies focused on inflammatory markers. A trend was observed for increased IL-10 and TNF-α in PM positives. These markers are however unspecific, thus a combination of multiple biomarkers involved in different pathophysiological pathways of PM is indicated. Of interest are inflammatory markers (TNF-R2, CXCL-13), markers of lipid metabolism (APO-B), angiogenesis (sFlt-1) and hormones (estradiol). As the majority of published studies tested biomarker levels only at delivery, more longitudinal cohort studies will be necessary to detect biomarkers during pregnancy that can predict PM.

References

Aug 1, 1975·Metabolism: Clinical and Experimental·L HillmanG Wulff
Jan 1, 1985·Transactions of the Royal Society of Tropical Medicine and Hygiene·M WatkinsonP G Lunn
Jan 1, 1983·Transactions of the Royal Society of Tropical Medicine and Hygiene·I A McGregorW Z Billewicz
Nov 24, 1999·The Journal of Infectious Diseases·A M MoormannS R Meshnick
Apr 4, 2000·Tropical Medicine & International Health : TM & IH·F P MockenhauptU Bienzle
Mar 10, 2001·The Journal of Infectious Diseases·A N TkachukS R Meshnick
Oct 27, 2001·Tropical Medicine & International Health : TM & IH·C E ShulmanK Marsh
Aug 1, 2002·American Journal of Reproductive Immunology : AJRI·Marie-Pierre Piccinni
Oct 29, 2002·The Journal of Infectious Diseases·Sujittra ChaisavaneeyakornVenkatachalam Udhayakumar
Feb 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elizabeth T AbramsStephen J Rogerson
Sep 27, 2003·The Journal of Infectious Diseases·Amorsolo L SuguitanDiane Wallace Taylor
Nov 19, 2003·Biochemical and Biophysical Research Communications·Douglas J PerkinsAltaf A Lal
Feb 3, 2004·American Journal of Infection Control·Judith Morrison, UNKNOWN Health Canada, Nosocomial and Occupational Infections Section
Apr 15, 2004·Placenta·B J BrabinJ Ordi
Jul 28, 2004·American Journal of Reproductive Immunology : AJRI·Elizabeth T AbramsSteven R Meshnick
Jul 28, 2004·Trends in Immunology·Anna Mondino, Francesco Blasi
Oct 19, 2004·Clinical Microbiology Reviews·Helen L Guyatt, Robert W Snow
Feb 8, 2005·Journal of Reproductive Immunology·Bernard J Brabin, Peter M Johnson
Aug 27, 2005·Malaria Journal·Elizabeth T AbramsSteven R Meshnick
Nov 16, 2006·PLoS Medicine·Atis MuehlenbachsPatrick E Duffy
Dec 26, 2006·Parasite Immunology·S R OstrowskiH Ullum
Jan 26, 2007·The Lancet Infectious Diseases·Meghna DesaiRobert D Newman
Jan 26, 2007·The Lancet Infectious Diseases·Stephen J RogersonDiane W Taylor
Jun 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Atis MuehlenbachsPatrick E Duffy
Jan 24, 2008·Infection and Immunity·Edward R KabyemelaPatrick E Duffy
Jan 31, 2008·Malaria Journal·Edward R KabyemelaPatrick E Duffy
Feb 19, 2008·The Journal of Infectious Diseases·Philippe BoeufStephen J Rogerson
Jul 9, 2008·International Journal for Parasitology·Mamadou DialloRonan Jambou
Sep 10, 2008·Proceedings of the National Academy of Sciences of the United States of America·Atis MuehlenbachsPatrick E Duffy
Sep 19, 2008·Statistics in Medicine·Julian P T HigginsJudith Anzures-Cabrera

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