Peripheral arousal-related hormones modulate norepinephrine release in the hippocampus via influences on brainstem nuclei

Behavioural Brain Research
T Miyashita, Cedric L Williams

Abstract

The peripheral hormone epinephrine (EPI) is known to modulate memory for arousing experiences. The mnemonic effects of EPI are attributed almost exclusively to actions on amygdala noradrenergic (NE) systems. EPI also increases neuronal activity in the locus coeruleus (LC), the primary source of NE to other limbic structures that process memory such as the hippocampus (HIPP). The actions of EPI on the LC suggest that its mnemonic properties may also be mediated by influencing NE output in the HIPP. To test this hypothesis, dialysate levels of NE were collected from the HIPP of male rats given an i.p. injection of saline that was followed 100 min later by i.p. EPI (0.3 mg/kg). NE levels sampled 20 min after EPI injection were significantly larger than baseline and continued to show significant peaks for 60 min. Experiment 2 examined whether peripheral signals initiated by EPI influence the HIPP via the nucleus of the solitary tract (NTS) by inactivating this nucleus with lidocaine prior to EPI injection. EPI injection did not increase NE levels sampled from the HIPP of rats given lidocaine into the NTS. EPI injection did produce significant elevations in HIPP NE levels in animals given a control solution into the NTS prior to the...Continue Reading

References

Oct 28, 1977·Brain Research·M Takigawa, G J Mogenson
Jan 1, 1986·Journal of Neurochemistry·J SchreursH Schulman
Nov 1, 1985·Behavioral and Neural Biology·D B SternbergJ L McGaugh
Feb 1, 1971·Proceedings of the Society for Experimental Biology and Medicine·W H Oldendorf
Sep 1, 1966·Experimental Neurology·M H ChaseC D Clemente
Nov 1, 1982·The Journal of Comparative Neurology·M Kalia, J M Sullivan
Feb 15, 1980·The Journal of Comparative Neurology·R LoyR Y Moore
Feb 1, 1993·Scientific American·E Tuomanen
Jan 1, 1996·Neuropsychobiology·G GerraF Brambilla
Feb 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·T SeidenbecherD Balschun
Aug 8, 1998·European Journal of Pharmacology·M J NijsenV M Wiegant
Feb 24, 2001·Autonomic Neuroscience : Basic & Clinical·H R Berthoud, W L Neuhuber
Feb 20, 2003·Neurobiology of Learning and Memory·Larry Cahill, Michael T Alkire
May 1, 1959·Science·H WEIL-MALHERBER TOMCHICK

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Citations

Dec 28, 2012·Behavioural Pharmacology·Mate TothVictoria Risbrough
Oct 7, 2006·Proceedings of the National Academy of Sciences of the United States of America·Gene-Jack WangJoanna S Fowler
Sep 14, 2007·Stress : the International Journal on the Biology of Stress·Mariana Paula CidNancy Alicia Salvatierra
Jan 8, 2013·Pharmacology, Biochemistry, and Behavior·Mariana Paula CidNancy Alicia Salvatierra
Aug 30, 2008·Neurobiology of Learning and Memory·Heather C AbercrombieRoxanne M Monticelli
Jan 9, 2007·Physiology & Behavior·Yantao ZuoRobert A Jensen
Dec 23, 2006·Neurobiology of Learning and Memory·Bernward WinterStefan Knecht
Aug 23, 2005·Neurobiology of Learning and Memory·Tobias MoorHartmut Schachinger
May 23, 2015·Frontiers in Neuroscience·Danielle M OsborneEwan C McNay
Aug 17, 2014·Neurobiology of Learning and Memory·Kasper SkriverJens Bo Nielsen
Apr 2, 2011·Neurobiology of Learning and Memory·Renee N SadowskiPaul E Gold
Oct 15, 2011·Laboratory animal research·Jung Hoon Choi, Moo-Ho Won
Feb 1, 2007·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Yusuf Ozgur Cakmak
Aug 9, 2018·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·P Souza-BragaM O Ribeiro

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