Peripheral autofluorescence findings in age-related macular degeneration

Acta Ophthalmologica
Matthew T WitmerSzilárd Kiss

Abstract

To describe the peripheral autofluorescent findings in patients with age-related macular degeneration (AMD) using ultrawide-field imaging. We retrospectively reviewed the ultra-wide-field autofluorescent images of all patients diagnosed with AMD or macular drusen at the Department of Ophthalmology of Weill Cornell Medical College from July 2010 to September 2011. Peripheral autofluorescent phenotypes included normal autofluorescence, focal pinpoint hyperfluorescence, granular fluorescent changes, patchy hypofluorescence, and reticular hypofluorescence. One hundred and ten consecutive patients (220 eyes) with a diagnosis of AMD or macular drusen were imaged using ultra-wide-field autofluorescent technology during the study period. Eighty-three patients (157 eyes) were included in the final analysis. Peripheral autofluorescent abnormalities were present in 63.6% of eyes with AMD versus 35.7% of control eyes (p=0.049). Granular fluorescent changes (p=0.0001) and patchy hypofluorescence (p=0.0015) were more common in eyes with advanced AMD than in eyes with early AMD or control eyes. Granular fluorescent changes were also more common in eyes with choroidal neovascularization (p=0.026) or geographic atrophy (p=0.0001). Patchy hypofl...Continue Reading

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Citations

Sep 8, 2012·Investigative Ophthalmology & Visual Science·Tobias DunckerFrançois C Delori
May 2, 2013·Ophthalmology·Akio OishiNagahisa Yoshimura
Feb 2, 2013·Survey of Ophthalmology·Matthew T Witmer, Szilárd Kiss
Nov 1, 2013·Acta Ophthalmologica·Anne-Laure Le PifferMarie-Bénédicte Rougier
Sep 27, 2016·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Angelica LyMichael Kalloniatis
Oct 10, 2018·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Antony J Wightman, Robyn H Guymer
Dec 24, 2018·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Lisa Nivison-SmithMichael Kalloniatis
Apr 25, 2019·Scientific Reports·Lijuan ChenJanet R Sparrow
Jul 5, 2017·BMC Ophthalmology·Makoto InoueAkito Hirakata
Oct 12, 2020·International Ophthalmology·Amin Xu, Changzheng Chen
Aug 8, 2020·Progress in Retinal and Eye Research·Steffen Schmitz-ValckenbergFrank G Holz

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