Peripheral B-Cell Subset Distribution in Primary Antiphospholipid Syndrome

International Journal of Molecular Sciences
Lorena Alvarez-RodriguezVictor Martínez-Taboada

Abstract

B-cell differentiation and B-cell tolerance checkpoints may be different in antiphospholipid syndrome (APS) from systemic lupus erythematosus (SLE) and can help to understand differences between them. Our aim was to define alterations of B-cell subsets in patients with primary APS (pAPS) and to compare them with SLE patients and healthy controls (HC). Cross-sectional study including three study groups: 37 patients with pAPS, 11 SLE patients, and 21 age- and gender-matched HC. We determined the frequencies of different B-cell subsets in peripheral blood naïve and memory compartments. In addition, we measured serum B cell-activating factor (BAFF) levels and circulating pro-inflammatory cytokines, such as IL-6, by commercial ELISA and CBA, respectively. Patients with pAPS showed a lower percentage of immature and naïve B cells than patients with SLE (p = 0.013 and p = 0.010, respectively) and a higher percentage of non-switched memory B cells than patients with SLE (p = 0.001). No differences either in the percentage of switched memory cells or plasma cells were found among the different groups. Serum BAFF levels were higher in SLE patients than in healthy controls and pAPS patients (p = 0.001 and p = 0.017, respectively). A signi...Continue Reading

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Citations

Feb 27, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Marina I KrivonosKhadizhat Sultangadzhieva
Mar 22, 2019·Frontiers in Immunology·Lorena Álvarez-RodríguezMarcos López-Hoyos
Feb 5, 2021·Biomedicines·Ilaria MormileFrancesca Wanda Rossi
Mar 17, 2021·Autoimmunity Reviews·Yannick DieudonnéVincent Gies

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Methods Mentioned

BETA
flow cytometry
ELISA
enzyme-linked immunosorbent assay
FACS

Software Mentioned

Multiset TM
FACSDiva
FCAP array
SPSS

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