Peripheral benzodiazepine receptor ligand Ro5-4864 inhibits isoprenaline-induced cardiac hypertrophy in rats

European Journal of Pharmacology
Amardeep JaiswalSubir Kumar Maulik

Abstract

Oxidative stress plays a significant role in the pathogenesis of cardiac hypertrophy. Peripheral benzodiazepine receptors are ubiquitously expressed in various tissues, including the heart. Peripheral benzodiazepine receptors have been reported to be involved in the protection of cells against oxygen radical damage. The present study was designed to determine whether Ro5-4864 (a peripheral benzodiazepine receptor ligand) can inhibit isoprenaline-induced cardiac hypertrophy. Male Wistar rats (body weight 150-200g) were administered, isoprenaline (5mg/kg, body weight, subcutaneously) alone or along with Ro5-4864 (0.1 and 0.5mg/kg, body weight, intraperitoneally) once daily for 14days. Control rats received normal saline subcutaneously (1.0ml/kg). Isoprenaline-induced changes in heart weight to body weight ratio, left ventricular wall thickness (M-mode echocardiography and gross morphometry) and myocyte size were significantly prevented by both the doses of Ro5-4864. Ro5-4864 also attenuated isoprenaline-induced increase in interstitial fibrosis, lipid peroxidation and changes in endogenous antioxidants (glutathione, superoxide dismutase and catalase). Isoprenaline-induced cardiac hypertrophy was associated with increased expressi...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Jul 1, 1975·The Journal of Clinical Investigation·W GrossmanL P McLaurin
Sep 1, 1989·Circulation Research·I J BenjaminW A Clark
Dec 1, 1989·The Journal of Clinical Investigation·B Nadal-Ginard, V Mahdavi
Oct 19, 1972·The New England Journal of Medicine·W B KannelM Feinleib
Feb 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·K W KinnallyH Tedeschi
Dec 22, 1993·Molecular and Cellular Biochemistry·P K SingalT P Thomas
Oct 1, 1993·Journal of Pharmacological and Toxicological Methods·N KaulP K Singal
Aug 1, 1996·Journal of the American College of Cardiology·A K DhallaP K Singal
May 5, 1999·Fundamental & Clinical Pharmacology·C J KenyonR Fraser
Nov 24, 1999·Biochemical and Biophysical Research Communications·F BonoJ M Herbert
Jun 29, 2000·Journal of Hypertension·N S DhallaT Netticadan
May 7, 2002·Journal of Molecular and Cellular Cardiology·Douglas B SawyerWilson S Colucci
Mar 8, 2003·Hypertension·Danelle BadenhorstGavin R Norton
Mar 11, 2003·The Journal of Biological Chemistry·Maike KrenzJeffrey Robbins
Apr 24, 2003·Molecular and Cellular Biochemistry·Aindrila ChattopadhyayAsoke G Datta
Aug 21, 2003·The Journal of Pharmacology and Experimental Therapeutics·Nathalie LeducqJean-Marc Herbert
May 1, 1959·Archives of Biochemistry and Biophysics·G L ELLMAN
Dec 4, 2003·Journal of the American College of Cardiology·Tzu-Hurng ChengJin-Jer Chen
Jan 7, 2004·Life Sciences·Roseli C FargesRosa M Ribeiro-do-Valle
Apr 7, 2004·Circulation·Norbert FreyJoseph A Hill
Dec 29, 2004·Cardiovascular Research·Guo-Xing ZhangYouichi Abe
Apr 12, 2005·Molecular Interventions·Marc W FarissSten Orrenius
Dec 28, 2006·Hypertension·Eiki Takimoto, David A Kass
Mar 14, 2007·Journal of Molecular and Cellular Cardiology·Guo-Xing ZhangShoji Kimura
Jul 21, 2007·The Journal of Pharmacology and Experimental Therapeutics·Fatou Nsoure ObameDidier Morin
Aug 28, 2007·Journal of Molecular and Cellular Cardiology·Mahesh P Gupta
Oct 16, 2008·Cardiovascular Research·Hiroyuki TsutsuiShouji Matsushima

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Citations

Dec 20, 2012·Oxidative Medicine and Cellular Longevity·Xiaolong QiJunjie Xiao
Jul 20, 2012·Canadian Journal of Physiology and Pharmacology·Subir Kumar MaulikSandeep Seth
Dec 22, 2015·Biochemical Pharmacology·Didier MorinBijan Ghaleh
Mar 8, 2012·Toxicology Mechanisms and Methods·Subir Kumar Maulik, Santosh Kumar
Mar 30, 2013·Journal of Cardiovascular Pharmacology and Therapeutics·Xinfeng WangShaoli Cheng
Mar 2, 2021·Molecular and Cellular Biochemistry·Ritesh Kumar SrivastavArshiya Shamim

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