Peripheral blood as a source of stem cells for regenerative medicine

Expert Opinion on Biological Therapy
Paola RomagnaniSergio Romagnani

Abstract

Converging evidence indicates that peripheral blood (PB) contains stem cells (SCs) with multidifferentiation potential, thus representing a potential source for regenerative medicine in several human disorders, as has also been confirmed by promising results obtained in several preliminary clinical trials. In addition to the classic haematopoietic SCs, PB also harbours endothelial progenitor cells, mesenchymal SCs, tissue-committed SCs and monocyte-like SCs. In spite of a series of different names and/or definitions, a large overlap seems to exist among surface markers, functions and origin of these different SC types. This review analyses the different subsets of SCs described in PB, the different hypotheses suggested to explain their origin, and the possible mechanisms that provide the basis for their biological potential.

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Citations

Feb 13, 2008·The Journal of Experimental Medicine·Benedetta MazzinghiPaola Romagnani
May 29, 2008·Journal of Gastroenterology and Hepatology·Olav A GressnerAxel M Gressner
Aug 1, 2007·Comparative Hepatology·Olav A GressnerAxel M Gressner
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Mar 13, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Olav A Gressner, Chunfang Gao
Aug 4, 2006·Journal of the American Society of Nephrology : JASN·Costanza SagrinatiPaola Romagnani

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