Peripheral-blood b-cell subset disturbances in inflammatory joint diseases induced by Tropheryma whipplei

PloS One
Maëlle Le GoffAlain Saraux

Abstract

To look for abnormalities in circulating B-cell subsets in patients with rheumatic symptoms of Whipple's disease (WD). Consecutive patients seen between 2010 and 2016 for suspected inflammatory joint disease were identified retrospectively. Results of standardized immunological and serological tests and of peripheral-blood B-cell and T-cell subset analysis by flow cytometry were collected. Patients with criteria suggesting WD underwent PCR testing for Tropheryma whipplei, and those with diagnosis of WD (cases) were compared to those without diagnosis (controls). We used ROC curve analysis to evaluate the diagnostic value of flow cytometry findings for WD. Among 2917 patients seen for suspected inflammatory joint disease, 121 had suspected WD, including 9 (9/121, 7.4%) confirmed WD. Proportions of T cells and NK cells were similar between suspected and confirmed WD, whereas cases had a lower proportion of circulating memory B cells (IgD-CD38low, 18.0%±9.7% vs. 26.0%±14.2%, P = 0.041) and higher ratio of activated B cells over memory B cells (4.4±2.0 vs. 2.9±2.2, P = 0.023). Among peripheral-blood B-cells, the proportion of IgD+CD27- naive B cells was higher (66.2%±18.2% vs. 54.6%±18.4%, P = 0.047) and that of IgD-CD27+ switched ...Continue Reading

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Citations

Nov 19, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Immacolata FaraoneLuigi Milella
Jun 12, 2021·Scientific Reports·Alice TisonAlain Saraux

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Methods Mentioned

BETA
biopsies
PCR
biopsy
flow cytometry
fluorescence-activated cell-sorter
flow

Software Mentioned

Statistical Package for the Social Sciences ( SPSS

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