Abstract
Chronic hepatitis C virus (HCV) infection is associated with B cell activation, although underlying mechanisms are unclear. To investigate B cell regulation during HCV infection, we measured bulk B cell CpG and Staphylococcus aureus Cowan-induced IgG Ab-secreting cell (ASC) frequency, HCV and tetanus-specific ASC frequency, BCR- and CD40L-dependent CD80/CD86 expression, and activation of memory CD4 cells. Immature transitional, naive, resting memory, mature activated, tissue-like memory, and plasma B cell subset frequencies, cell cycling, and intrinsic apoptosis were quantified. We observed intact or enhanced tetanus-specific and total IgG ASC frequency, serum IgG, BCR- and CD40L-dependent CD80/CD86 expression, and CD40L-dependent bulk B cell activation of memory CD4 cells in HCV infection. HCV-specific ASCs were observed in HCV-infected but not control subjects, although frequencies were lower compared with tetanus-specific cells. Immature transitional and mature activated B cell subset frequencies were increased in HCV-infected subjects, with immature transitional frequency associated with liver inflammation and serum B cell-activating factor. Mature activated B cells less commonly expressed Ki67, more commonly expressed Bcl2...Continue Reading
References
Feb 1, 1992·The Journal of Clinical Investigation·A ShiraiD M Klinman
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R PahwaS Pahwa
Feb 1, 1997·Seminars in Arthritis and Rheumatism·R W McMurray, K Elbourne
May 8, 1998·Seminars in Arthritis and Rheumatism·K E HansenA J Bridges
Jul 22, 1998·The Journal of Experimental Medicine·L MorrisJ P Moore
Nov 7, 1998·Seminars in Arthritis and Rheumatism·D BuskilaE Sikuler
Oct 19, 1999·Arthritis and Rheumatism·P CacoubP Opolon
Jan 1, 2000·Arthritis and Rheumatism·P LamprechtW L Gross
Nov 21, 2000·The Journal of Experimental Medicine·M BattenF Mackay
Nov 23, 2000·AIDS·H ValdezM M Lederman
Feb 7, 2001·Proceedings of the National Academy of Sciences of the United States of America·S WellerJ C Weill
Apr 25, 2001·Clinical Immunology : the Official Journal of the Clinical Immunology Society·D D AnthonyP S Heeger
May 18, 2001·Journal of Virology·N H GruenerP Klenerman
Aug 16, 2001·Proceedings of the National Academy of Sciences of the United States of America·S MoirA S Fauci
Sep 28, 2001·Journal of Gastroenterology·I Nakamura, M Imawari
May 11, 2002·AIDS·Hernan ValdezDonald D Anthony
Sep 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Heiner WedemeyerBarbara Rehermann
Oct 2, 2002·Annals of Internal Medicine·Anna Linda ZignegoPaolo Gentilini
Mar 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jianhua NiLynn B Dustin
Feb 14, 2004·Immunological Reviews·Rita CarsettiHedda Wardmann
Sep 9, 2004·The Journal of Experimental Medicine·Susan MoirAnthony S Fauci
Feb 11, 2005·Blood·Gary P SimsPeter E Lipsky
Jun 28, 2005·Journal of Clinical Immunology·Natalia Soriano-SarabiaAlejandro Vallejo
Dec 13, 2005·Proceedings of the National Academy of Sciences of the United States of America·Domenico RosaSergio Abrignani
Jan 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amanda K CussStuart G Tangye
Feb 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Angela MalaspinaAnthony S Fauci
Mar 31, 2006·Journal of Virology·Vito RacanelliFranco Dammacco
Apr 29, 2006·Blood·Kehmia TitanjiFrancesca Chiodi
Jun 1, 2006·Rheumatology·M FabrisS De Vita
Jun 20, 2006·Rheumatology·D SèneP Cacoub
Oct 21, 2006·Blood·Angela MalaspinaAnthony S Fauci
Dec 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jason HoAnthony S Fauci
Oct 19, 2007·Blood·Edgar D CharlesLynn B Dustin
Jan 8, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Federica CapolunghiRita Carsetti
Apr 25, 2008·Current Opinion in Immunology·David Allman, Shiv Pillai
Citations
Mar 19, 2013·PLoS Neglected Tropical Diseases·Lucja A LabudaHermelijn H Smits
Apr 29, 2011·PloS One·Zhihui ChenZhongtian Qi
May 6, 2014·The Journal of Infectious Diseases·Nicolas DaubyArnaud Marchant
Sep 7, 2012·Clinical & Developmental Immunology·Valli De ReOmbretta Repetto
May 3, 2012·Advances in Hematology·Corry van den Bosch
Apr 6, 2016·Frontiers in Immunology·Gitit ShahafRamit Mehr
Nov 27, 2014·Human Vaccines & Immunotherapeutics·Paolo PalmaAlberto Cagigi
Dec 31, 2015·The Journal of Infectious Diseases·Nicolas DaubyArnaud Marchant
Feb 26, 2014·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Sven ReicheChristian Jassoy
Mar 21, 2017·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Silvia LeePatricia Price
Oct 3, 2013·Experimental Biology and Medicine·Haibo SunJunqi Niu
Nov 17, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maude BoisvertArash Grakoui
May 22, 2018·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Thomas LiechtiAlexandra Trkola
Dec 16, 2017·Blood·Felicia A TucciRalf Küppers
May 5, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lauren E HolzBarbara Rehermann
Aug 14, 2018·Parasite Immunology·Mandar PatgaonkarSulabha Pathak
Apr 1, 2016·PloS One·Alena RothAlmut Meyer-Bahlburg
Feb 17, 2018·Emerging Microbes & Infections·Chen TianChao Wu
May 9, 2015·Infectious Diseases of Poverty·Xin-Xu LiXiao-Nong Zhou
Jan 23, 2015·Journal of Medical Virology·Anita KohliAnthony S Fauci
Jan 16, 2020·PloS One·Gigi Y LiuStephen P Juraschek
Nov 22, 2017·Journal for Immunotherapy of Cancer·Rahima JamalWilson H Miller
Sep 7, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Issam ToutUzma Hasan
Sep 21, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hiroyoshi DoiDavid E Kaplan
Dec 10, 2015·PloS One·Elane Reyes-AvilésDonald D Anthony
Sep 14, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Abhishek DasMala K Maini
Nov 20, 2016·Scientific Reports·Li-Yuan ChangDavid E Kaplan
Jun 12, 2020·Clinical Microbiology Reviews·Joshua S DavisMichael Boyle
Jan 25, 2013·AIDS·Simone PensierosoGabriella Scarlatti
Jan 23, 2019·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Yong LiuYanfang Jiang
Dec 29, 2019·Scientific Reports·Marco CagninPatrizia Pontisso
Dec 11, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Natalia V GiltiayEdward A Clark
Mar 26, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Zoe RaglowYu-Jui Y Wan
Sep 27, 2014·Journal of Viral Hepatitis·B OlivieroM U Mondelli
Aug 16, 2017·Experimental and Therapeutic Medicine·Fanyun KongLai Wei
Apr 29, 2020·Gut·Anton LutckiiNiklas K Björkström
Nov 13, 2020·Viral Immunology·Hanan MoustafaMai Moaaz
Nov 25, 2020·Scientific Reports·Fadwa A AbdelwahabOmnia El-Badawy
Jan 20, 2021·The Journal of Clinical Investigation·Eduardo SalinasArash Grakoui