Peripheral blood cell count ratios are predictive biomarkers of clinical response and prognosis for non-surgical esophageal squamous cell carcinoma patients treated with radiotherapy.

Journal of Clinical Laboratory Analysis
Xiaohui ZhiLiqing Zhou

Abstract

Peripheral blood cell count ratios, including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR), have been reported to be prognostic factors in many malignancies as markers of inflammation and immune status. The aim of this study was to determine whether NLR, PLR, or LMR can be clinical response and prognostic biomarkers of non-surgical esophageal squamous cell carcinoma (ESCC) patients treated with radiotherapy. 193 non-surgical ESCC patients who underwent radiotherapy were retrospectively analyzed. The peripheral blood cell count ratios were obtained before, during (weekly) and at the end of the treatment. Then, we compared the subsequent results with the corresponding pretreatment values and computed the rates of change, which were defined as cNLR, cPLR, and cLMR. Univariate and multivariate Cox regression analyses were used for overall survival (OS). Ordinal logistic regression was used to analyze the clinical response. In multivariate analysis, cNLR at week 4(P = .026) and week 5(P = .025) during radiotherapy were significantly associated with OS, along with BMI, tumor stage, tumor length, tumor location, and grade of adverse events. Besides, BMI, tumor sta...Continue Reading

References

Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Oct 16, 2007·Cancer Cell·Thorsten HagemannToby Lawrence
Dec 20, 2007·American Journal of Clinical Oncology·Satoshi TakeuchiKeiji Nihei
Mar 31, 2009·International Journal of Radiation Oncology, Biology, Physics·Madoka MorotaTakashi Yamashita
Jul 15, 2009·Current Opinion in Pharmacology·Mohamed M M Abdel-LatifDermot Kelleher
Oct 1, 2009·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·R H MakT S Hong
Mar 23, 2010·Cell·Sergei I GrivennikovMichael Karin
Jul 8, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Wen-Jie Cai, Pei-Ling Xin
Nov 3, 2010·Journal of Thrombosis and Haemostasis : JTH·N M Bambace, C E Holmes
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Jul 22, 2011·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Viren AsherAnish Bali
Mar 16, 2012·Nature Reviews. Cancer·Wolf Herman FridmanJérôme Galon
Sep 14, 2012·Frontiers in Oncology·Kirsten LauberClaus Belka
May 1, 2013·Journal of Epidemiology·Yingsong LinHideo Tanaka
Feb 26, 2014·World Journal of Gastrointestinal Oncology·Ioannis A Voutsadakis
May 27, 2015·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Michael PinkawaMichael J Eble
Jun 25, 2015·Nature Reviews. Cancer·Holly E BarkerKevin J Harrington
Mar 1, 2016·Oncogene·E W LinA K Rustgi
Mar 5, 2016·Oncoimmunology·Laura SuraceMaries van den Broek
Mar 8, 2016·European Journal of Cancer Care·Y-F HeB Hu
Dec 31, 2016·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·N HiraharaY Tajima
Feb 6, 2018·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Ryoko SuzukiRitsuko Komaki
Jul 19, 2018·Annals of Surgical Oncology·Yusuke IshibashiHideki Ueno

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.