PMID: 9533168Apr 9, 1998Paper

Peripheral blood lymphocytes of bipolar affective patients have a histone synthetic profile indicative of an active cell state

Progress in Neuro-psychopharmacology & Biological Psychiatry
T G SourlingasK E Sekeri-Pataryas

Abstract

1. Although abnormalities of the immune system have been described in depression, no information exists regarding the biochemical parameters which could characterize the physiological state of lymphocytes from patients with bipolar affective disorder. 2. Lymphocytes of normal control subjects are known to be in the Go resting phase of the cell cycle. Histone synthesis is characteristically different during the Go, G1/G2 and the S phases of the cell cycle. As such, it can be used as a biochemical marker with which to distinguish between cycling and noncycling cells. 3. In order to investigate the possibility of whether or not the lymphocytes of patients with bipolar affective disorder are in an activated state, typical of cycling cells, total histone and histone variant synthesis were analysed in peripheral blood lymphocytes of a group of 12 patients with bipolar affective disorder and 7 normal controls. 4. According to the histone variant synthesis pattern, lymphocytes of patients in normothymia have values similar to those of controls, i.e., of noncycling cells, while patients in either the depressed or the manic phase have values intermediate to those of resting and cycling cells. 5. This study shows that histone synthesis ca...Continue Reading

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Citations

Mar 28, 2013·Expert Opinion on Medical Diagnostics·Antonio Lucio TeixeiraMoisés E Bauer
Sep 1, 2000·Acta Neuropsychiatrica·R W KupkaH A Drexhage
Oct 31, 2002·Human Psychopharmacology·Ahmed A WadeeMichael Maes
Aug 9, 2017·Frontiers in Cellular Neuroscience·Yun-Fang JiaMarin Veldic
Nov 10, 2009·Ultrastructural Pathology·Margarita Chrysanthou-PiterouMarietta R Issidorides

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