PMID: 11311963Apr 20, 2001Paper

Peripheral blood mitochondrial DNA content is inversely correlated with insulin secretion during hyperglycemic clamp studies in healthy young men

Diabetes Research and Clinical Practice
K S ParkH K Lee

Abstract

Abnormalities in mitochondrial DNA(mtDNA) have been implicated in the pathogenesis of diabetes mellitus. We recently reported that decreased mtDNA content precedes the development of diabetes mellitus and is associated with parameters of insulin resistance. In this study, we examined whether there is any relation between mtDNA content and insulin secretion. We compared the mtDNA content of peripheral blood leukocytes with the parameters of insulin secretion measured by hyperglycemic clamp in a group of healthy young men. There were statistically significant correlations between mtDNA content in peripheral blood and fasting plasma insulin (r=-0.43, P<0.05) and C-peptide levels (r=-0.44, P<0.05). MtDNA content also correlated negatively with acute insulin response(r=-0.48, P<0.05), late insulin response (r=-0.50, P<0.05) during hyperglycemic clamp and insulin secretion after glucagon stimulation (r=-0.60, P<0.01). mtDNA content in peripheral blood correlated negatively with homeostasis model (HOMA) insulin resistance (r=-0.45, P<0.05) although it did not correlate with the insulin insensitivity index (M/I) during hyperglycemic clamp. In summary, the mtDNA content of peripheral blood correlated negatively with indices of insulin r...Continue Reading

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Citations

Oct 22, 2003·Molecular Genetics and Metabolism·Gregory M Enns
Dec 6, 2001·Diabetes Research and Clinical Practice·H K Lee
Nov 17, 2009·Biochimica Et Biophysica Acta·Hong Kyu LeeEun Bo Shim
Apr 25, 2007·Diabetes Research and Clinical Practice·Young Min ChoHong Kyu Lee
Nov 19, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Dae Won JunMin Ho Lee
Jan 25, 2019·Diabetes/metabolism Research and Reviews·Hongdi CaoLi Fang
Feb 13, 2010·The Journal of Clinical Endocrinology and Metabolism·Erwin ReilingLeen M 't Hart
May 6, 2004·Annals of the New York Academy of Sciences·Hong Kyu Lee
Mar 15, 2019·Journal of Physiology and Biochemistry·José L SantosJosé Galgani
Aug 27, 2021·Experimental Cell Research·Irena AudzeyenkaAgnieszka Piwkowska

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