Peripheral blood mononuclear cells of patients with Indian visceral leishmaniasis suppress natural killer cell activity in vitro

Transactions of the Royal Society of Tropical Medicine and Hygiene
G ChakrabartiS Bandyopadhyay

Abstract

Peripheral blood mononuclear cells (PBMC) of patients with Indian visceral leishmaniasis (VL) suppressed the natural killer cell (NK) activity of normal human PBMC in vitro in a dose-dependent manner. Adherent monocytes, but not the non-adherent lymphocytes of VL patients suppressed NK activity through soluble mediators. The level of suppression seen in different patients was variable.

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