PMID: 8611448Apr 1, 1996Paper

Peripheral blood progenitor cell collections in multiple myeloma: predictors and management of inadequate collections

British Journal of Haematology
H M PrinceA Keith Stewart

Abstract

Thirty-seven patients with previously treated multiple myeloma (MM) underwent peripheral blood progenitor cell (PBPC) collection following high-dose cyclophosphamide and GM-CSF or sequential IL-3 and GM-CSF. Patients with an inadequate collection were considered for a second or third collection. 25 patients underwent subsequent autotransplant. The only variable predictive of CFU-GM yield was the extent of prior melphalan therapy. All repeat collections were unsuccessful and patients infused with an autograft obtained from multiple sets of collections had a high incidence of delayed engraftment. We conclude that melphalan should be avoided or PBPC collection performed early in the disease course in patients who are potential transplant candidates.

Citations

Jan 1, 1997·Stem Cells·M EderA Ganser
Oct 29, 2009·Blood·A Keith StewartJesus F San-Miguel
Sep 28, 2007·Drugs & Aging·Hang QuachLinda Mileshkin
Apr 25, 2007·Leukemia & Lymphoma·Federica CavalloAntonio Palumbo
May 1, 2013·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Itır Şirinoğlu DemirizFevzi Altuntaş
Jul 16, 2005·Leukemia & Lymphoma·Linda Mileshkin, H Miles Prince
May 21, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Kirsten E HerbertMiles Prince
Nov 24, 2004·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Kazuma IkedaMine Harada
Sep 1, 2000·Bone Marrow Transplantation·A CorsoC Bernasconi
Nov 7, 2017·World Journal of Transplantation·Whitney D Wallis, Muzaffar H Qazilbash
Jul 15, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J F DiPersioC M Baum
Dec 1, 2019·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Eshana E ShahThomas G Martin

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