PMID: 6237013Jul 1, 1984

Peripheral blood T-cell subsets studied by monoclonal antibodies in type 1 (insulin-dependent) diabetes: effect of blood glucose control

M RodierJ Clot


Peripheral T lymphocyte subsets were investigated, using monoclonal antibodies, in 14 patients with acute diabetes of duration less than 1 month (before insulin treatment) and after prolonged strict blood glucose control, and also in 40 healthy volunteers. At the time of diagnosis, the percentage total T cells was decreased (67.6 +/- 8.4 versus 72.8 +/- 6.6%), but T4 'helper' cells and T8 'suppressor/cytotoxic' cells were in the normal range. The T4/T8 ratio was not significantly higher than in the control group and B-cell percentages were increased (IgS: 18.3 +/- 7.1 versus 12.4 +/- 4.9%). The second T cell enumeration, performed after sustained normoglycaemia, showed a normal total T cell percentage and a decrease in the T4/T8 ratio depending on a decrease of T4 cells (38.3 +/- 12.8 versus 49.3 +/- 13.4), without any change of T8 lymphocytes; B cells remained elevated. These results suggest that insulin deficiency/metabolic derangement was responsible for an imbalance of circulating lymphocytes and underlines the importance of metabolic control in the assessment of such immunological parameters.


Apr 1, 1992·Diabetes/metabolism Reviews·C Giordano
Jul 15, 1987·Klinische Wochenschrift·A G ZieglerH Mehnert
Mar 1, 1988·Medical Hypotheses·E Papadopulos-Eleopulos
May 1, 1992·Diabetes Research and Clinical Practice·E GuastamacchiaG M Nardelli
Aug 1, 1988·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·H Hyöty
Mar 1, 1989·Diabetic Medicine : a Journal of the British Diabetic Association·F d'Amore, O D Wolthers
Dec 1, 1994·Diabetic Medicine : a Journal of the British Diabetic Association·P Pozzilli, R D Leslie
Apr 2, 2003·Environmental Technology·Z ReddadP Le Cloirec
Oct 1, 1987·Diabetes/metabolism Reviews·J S Skyler
Mar 9, 2006·Clinical Orthopaedics and Related Research·Matthew E CunninghamFrank P Cammisa
Aug 1, 1991·Clinical and Experimental Immunology·J IlonenM L Käär


Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·E L ReinherzS F Schlossman
Nov 25, 1972·Lancet·R B Tattersall, D A Pyke
Aug 1, 1974·Diabetes·A C MacCuishW J Irvine
Jan 1, 1981·The American Journal of Medicine·W Gepts, P M Lecompte
Jan 1, 1981·Endocrine Reviews·N R Farid, J C Bear
Apr 1, 1982·The New England Journal of Medicine·R A JacksonG S Eisenbarth

Related Concepts

Monoclonal Antibodies
TC2 Cells
Insulin Resistance
Helper-Inducer T-Lymphocyte
Diabetes, Autoimmune
Tr1 Cells
Metabolic Diseases
Blood Glucose

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.