Peripheral CD8 T-cell responses to apoptotic cell proteins and peptides

Critical Reviews in Immunology
Yu Feng Peng, Keith B Elkon

Abstract

The immune system must contend with the billions of cells that are turned over on a daily basis; many of these cells derived from the immune system itself. Recent evidence suggests that the apoptotic cells are processed and presented through classical pathways for MHC II presentation to CD4 T cells and also are cross-presented through a phagosome-cytosolic pathway or released into the cytosol for presentation to CD8 T cells. It appears that the continuous presentation of self-peptides is required for active maintenance of T-cell tolerance. Although for both CD4 and CD8 T cells, anergy is a dominant pathway for tolerance, presentation of self-peptides to CD8 and CD4 T may induce different responses. Phagocytosis of apoptotic cells leads to the production of TGF-beta and/or IL-10 by antigen-presenting cells and there is evidence to suggest that these cytokines favor the generation of CD4 T regulatory cells following encounter with self-antigen. In contrast, CD8 T cells undergo brief activation, an abortive proliferation ultimately leading to reduced long-term survival. The relative quantity and quality of all three signals of TCR engagement, costimulation versus coinhibition and quality of the cytokine response, distinguish T-cel...Continue Reading

Citations

Jun 1, 2011·Cellular and Molecular Life Sciences : CMLS·Jonathan D Katz, Edith M Janssen
Jan 1, 2011·Cancers·Stefan Nierkens, Edith M Janssen
Aug 20, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rachel A RebouletEdith M Janssen

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