Peripheral chemoreceptor control of fetal renin responses to hypoxia and hypercapnia

Circulation Research
C E WoodH Raff

Abstract

The renin response to hypoxia in late gestation fetal sheep has been well characterized. However, the renin response to asphyxia--the combination of hypoxia and hypercapnia--has not been extensively studied. The purpose of this study was to determine 1) the interaction of hypoxia and hypercapnia in the control of renin secretion in late gestation fetal sheep and 2) the role of peripheral arterial chemoreceptors therein. Chronically catheterized fetal sheep (intact or sinoaortic denervated) were exposed to hypoxia and/or hypercapnia for 30 minutes. Hypercapnia alone had no effect on plasma renin activity or aldosterone but did result in a significant increase in angiotensin II. Hypercapnia combined with hypoxia resulted in a significant increase in renin activity, angiotensin II, and aldosterone. Sinoaortic denervation attenuated the renin and angiotensin II responses to hypercapnia plus hypoxia. The increase in renin and angiotensin II in response to hypercapnia with or without concomitant hypoxia strongly correlated with the magnitude of the decrease in arterial pH in intact fetuses only. Hypoxia alone and in concert with hypercapnia increased mean arterial pressure and decreased heart rate in intact but not sinoaortic denerva...Continue Reading

References

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Citations

Dec 13, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Melanie J Powers, Charles E Wood
Oct 28, 2010·Reproductive Sciences·Ravi GoyalLawrence D Longo
Jun 23, 2011·Biomedical Engineering Online·B Silvano ZanuttoMax E Valentinuzzi
Nov 2, 2002·The Journal of Physiology·Scott C Purinton, Charles E Wood
Jun 7, 2006·Journal of the Society for Gynecologic Investigation·Charles E Wood, Damian Giroux
Apr 25, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Charles E Wood, Maureen Keller-Wood
Jul 16, 2015·American Journal of Physiology. Endocrinology and Metabolism·Elizabeth A NewbyCharles A Ducsay
Dec 22, 1999·The American Journal of Physiology·C E Wood, H Tong
Aug 1, 1997·Acta Paediatrica·D N Pereira, R S Procianoy
Oct 9, 2020·Journal of Clinical Medicine·Masahiko ShigemuraJacob I Sznajder
Aug 13, 1999·The American Journal of Physiology·M A BraaksmaJ G Aarnoudse
Sep 1, 1991·The American Journal of Physiology·T A Cudd, C E Wood

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