Peripheral "chicken" obestatin administration does not affect feed intake and gut muscle contractility of meat-type and layer-type chicks (Gallus gallus domesticus)

Regulatory Peptides
Zhigang SongJ Buyse

Abstract

Obestatin has recently been discovered in the rat stomach. As for ghrelin, the 23-amino acid obestatin is also derived from post-translational processing of the prepro-ghrelin gene but seems to have opposite effects on feed intake. In avian species, ghrelin is mainly present in the proventriculus and decreases feed intake, as opposed to its orexigenic properties in mammals. An obestatin-like sequence was also found in the avian ghrelin precursor protein but the potential involvement of this peptide in appetite regulation of chickens is unclear. We therefore investigated the effects of a single peripheral administration of this predicted "chicken" obestatin peptide on voluntary feed intake of 7- to 9-day-old meat-type and layer-type chicks. "Chicken" obestatin was injected intraperitoneally or intravenously at a dose of 1 nmol or 10 nmol/100 g body weight and feed intake was measured up to 4 h post injection. None of these treatments did reveal any effect of the putative "chicken" obestatin on appetite of either meat-type of layer-type chicks. Furthermore, "chicken" obestatin also failed to affect the in vitro contractility of muscle strips from crop and proventriculus. In conclusion, in the given experimental settings, the puta...Continue Reading

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Citations

May 28, 2013·General and Comparative Endocrinology·Zhigang SongJohan Buyse
May 2, 2013·General and Comparative Endocrinology·Hiroyuki KaiyaMikiya Miyazato
Aug 6, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·B AvauI Depoortere
Dec 17, 2014·General and Comparative Endocrinology·Inge SeimLisa K Chopin

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