Peripheral circadian rhythms in the liver and white adipose tissue of mice are attenuated by constant light and restored by time-restricted feeding

PloS One
Daisuke YamamuroShun Ishibashi

Abstract

Disturbance of circadian rhythms underlies various metabolic diseases. Constant light exposure (LL) is known to disrupt both central and peripheral circadian rhythms. Here, we attempted to determine whether the effects of LL are different between various peripheral tissues and whether time-restricted feeding restores the circadian rhythms especially in white adipose tissue (WAT). Six-week-old mice were subjected to three feeding regimes: ad libitum feeding under light/dark phase (LD), ad libitum feeding under LL cycle, and restricted feeding at night-time under LL cycle with a normal chow. After 3 weeks, we compared body weight, food intake, plasma levels of lipids and glucose, and the expression patterns of the clock genes and the genes involved in lipid metabolism in the liver and WAT. The mice kept under LL with or without time-restricted feeding were 5.2% heavier (p<0.001, n = 16) than the mice kept under LD even though the food intakes of the two groups were the same. Food intake occurred mostly in the dark phase. LL disrupted this pattern, causing disruptions in circadian rhythms of plasma levels of triglycerides (TG) and glucose. Time-restricted feeding partially restored the rhythms. LL eliminated the circadian rhythms ...Continue Reading

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Citations

Aug 6, 2020·International Journal of Molecular Sciences·Valentina S RumanovaMichal Zeman
Dec 29, 2020·Journal of Neurochemistry·M Renate Buijink, Stephan Michel
Mar 17, 2021·Journal of Pharmacokinetics and Pharmacodynamics·Panteleimon D Mavroudis, William J Jusko
May 10, 2021·Current Opinion in Clinical Nutrition and Metabolic Care·Georgios K Paschos
Oct 1, 2021·Nature·Matt UlgheraitMimi Shirasu-Hiza
Jan 9, 2022·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Emily N C ManoogianSatchidananda Panda

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Methods Mentioned

BETA
chips
PCR
environmental stresses

Software Mentioned

Midline Estimating Statistic Of Rhythm ( MESOR )
Graph Pad Prism

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