Peripheral clonal elimination of functional T cells

Science
L A JonesA M Kruisbeek

Abstract

A major mechanism for generating tolerance in developing T cells is the intrathymic clonal deletion of T cells that have receptors for those self antigens that are presented on hematopoietic cells. The mechanisms of tolerance induction to antigens not expressed in the thymus remain unclear. Tolerance to self antigens can be generated extrathymically through the induction of clonal nonresponsiveness in T cells with self-reactive receptors. A second mechanism of extrathymic tolerance was identified: clonal elimination of mature T cells with self-reactive receptors that had previously displayed functional reactivity.

References

Mar 1, 1990·The Journal of Experimental Medicine·S R Webb, J Sprent
Jun 15, 1990·Science·R H Schwartz
Apr 1, 1990·The Journal of Experimental Medicine·H R MacDonaldY Chvatchko
Oct 1, 1990·The Journal of Experimental Medicine·B L RellahanL A Matis
Nov 1, 1990·The Journal of Experimental Medicine·L A JonesA M Kruisbeck
Jul 1, 1989·The Journal of Experimental Medicine·N S LiaoD H Raulet
Nov 24, 1989·Science·F RamsdellB J Fowlkes
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·K M MurphyD Y Loh
Mar 1, 1989·The Journal of Experimental Medicine·S X QinH Waldmann
Apr 24, 1987·Cell·J W KapplerP Marrack
Apr 1, 1980·The Journal of Experimental Medicine·A L Glasebrook, F W Fitch

❮ Previous
Next ❯

Citations

Oct 1, 1998·European Journal of Immunology·M J Martínez-LorenzoA Anel
Jan 1, 1994·Arthritis and Rheumatism·J D MountzC K Edwards
Dec 18, 2001·International Journal of Cancer. Journal International Du Cancer·S L KominskyH M Johnson
Jan 1, 1991·Springer Seminars in Immunopathology·K Nomoto, Y Yoshikai
Feb 28, 1998·Immunologic Research·C C Maier, M I Greene
Jan 1, 1991·Immunologic Research·T A BarrettJ A Bluestone
Jan 1, 1996·Immunologic Research·V K Singh, K Nagaraju
Nov 15, 2002·International Journal of Hematology·Richard K BurtAlberto M Marmont
Nov 1, 1991·Immunology Letters·L Fesus
Oct 1, 1992·Immunology Today·G Kroemer, C Martínez
Apr 1, 1992·Current Opinion in Immunology·B ArnoldG J Hämmerling
Jun 1, 1994·Current Opinion in Immunology·D R Green, D W Scott
Jan 1, 1993·Transplant Immunology·P F HalloranJ Madrenas
May 23, 2001·Free Radical Biology & Medicine·M A PahlavaniA Richardson
Dec 1, 1991·Current Opinion in Immunology·V Kumar, E E Sercarz
Apr 1, 1996·Current Opinion in Immunology·A M Kruisbeek, D Amsen
Mar 21, 1998·Trends in Microbiology·C A Michie, J Cohen
Aug 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·M A BlackmanP Marrack
Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·L E Fields, D Y Loh
Aug 1, 1995·Proceedings of the National Academy of Sciences of the United States of America·Y ModiglianiJ Salaün
Mar 19, 1996·Proceedings of the National Academy of Sciences of the United States of America·C C Goodnow
Jan 1, 1992·The Journal of Experimental Medicine·E E Eynon, D C Parker
Jan 1, 1992·The Journal of Experimental Medicine·T A BarrettJ A Bluestone
Jun 1, 1992·The Journal of Experimental Medicine·W HeldH Acha-Orbea
Jul 1, 1992·The Journal of Experimental Medicine·L M Spain, L J Berg
Aug 1, 1996·The Journal of Experimental Medicine·M A Alexander-MillerJ A Berzofsky
Nov 1, 2002·Current Opinion in Rheumatology·Yolanda Braun-Moscovici, Daniel E Furst
Apr 20, 2002·Transplantation·Anna ValujskikhPeter S Heeger
Feb 1, 1993·Immunological Reviews·H Acha-OrbeaH R MacDonald
Dec 1, 1994·Immunological Reviews·D KabelitzK Pechhold
Dec 1, 1994·Immunological Reviews·R S LiblauH O McDevitt

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.