PMID: 1202104Nov 1, 1975Paper

Peripheral control of drinking: gastrointestinal filling as a negative feedback signal, a theoretical and experimental analysis

Journal of Comparative and Physiological Psychology
J D DavisM W Levine

Abstract

The studies described here investigated the hypothesis that the osmotic postingestional satiety signal proposed by McCleary operates through a mechanism related to gut filling rather than by osmotically induced shifts of fluid from osmoreceptors in the brain. A control theory model is presented, which was designed to make quantitatively explicit the hypothesis under question. The results showed that when mannitol, which is not absorbed from the intestine, is added to a highly palatable saccharin-glucose mixture, the amount of fluid consumed decreased in inverse proportion to the mannitol concentration. Mannitol was also shown to block fluid absorption from the intestine at a low concentration (approximately .070 M) and at higher concentrations to lead to a net flux of fluid into the intestinal lumen. It was also shown that mannitol in concentrations that reduced the intake of the palatable solution did not induce thirst when the animals were in water balance. It did induce thirst, however, when the animals were tested in a state of negative water balance. The results of these studies, considered as a whole, support the view that McCleary's osmotic postingestional satiety signal acts as an intestinal distention signal rather tha...Continue Reading

Citations

Jul 1, 1977·Physiology & Behavior·D Wirtshafter, J D Davis
Dec 1, 1978·Physiology & Behavior·B J Collins, J D Davis
Apr 1, 1978·Physiology & Behavior·I L Bernstein, M V Vitiello
May 1, 1979·Physiology & Behavior·D A Fitts, J W Wright
Jul 1, 1980·Physiology & Behavior·R J Waldbillig, M O'Callaghan
Jan 1, 1981·Physiology & Behavior·G BárdosG Adám
Feb 1, 1982·Physiology & Behavior·N Geary, G P Smith
Jul 1, 1984·Physiology & Behavior·A C Spector, J C Smith
Nov 1, 1984·Physiology & Behavior·L R Kushner, D G Mook
Oct 1, 1984·Physiology & Behavior·G Bardos, J Laszy
Aug 1, 1994·Physiology & Behavior·T R Houpt
Jan 1, 1982·Neuroscience and Biobehavioral Reviews·K A Houpt
Jan 1, 1996·Neuroscience and Biobehavioral Reviews·G P Smith
Jan 16, 2002·Physiology & Behavior·G Bárdos
Mar 14, 2000·Physiology & Behavior·B O WardP G Clifton
Aug 19, 2007·Chemical Senses·Theresa L WhiteSteven L Youngentob
Aug 13, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J I GlendinningH N Spain
Jul 30, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yada TreesukosolAlan C Spector
May 1, 1984·Journal of the Autonomic Nervous System·M Fantino
May 8, 2007·Physiology & Behavior·Edward M Stricker, Myriam L Hoffmann
Jun 14, 2006·Developmental Psychobiology·Aron Weller
Feb 13, 2001·Appetite·G P Smith
Sep 2, 2005·Chemical Senses·John I GlendinningKun Hao Zheng
Jan 6, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Carrie A SmithEdward M Stricker
Jan 25, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A WellerG P Smith
Oct 20, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J P BairdJ B Travers
May 8, 1999·The American Journal of Physiology·G van DijkM W Schwartz

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