PMID: 6973156Jun 1, 1981Paper

Peripheral conversion of L-5-hydroxytryptophan to serotonin induces drinking in rats

Pharmacology, Biochemistry, and Behavior
D C KiktaJ E Greenleaf

Abstract

Female rats administered serotonin (0.25 to 4.0 mg/kg, s.c.) showed a dose-dependent increase in water intake. The dipsogenic response was nearly maximal when 2 mg/lg was administered s.c. and plateaued by 2 hr after treatment. l-5-Hydroxytryptophan (5-HTP), the precursor of serotonin, is also a potent dipsogen which induces drinking by way of the renin-angiotensin system. The possibility that the dipsogenic activity of 5-HTP is dependent on decarboxylation to serotonin was the objective of these studies. Either benserazide (30 mg/kg. s.c.), a central and peripheral decarboxylase inhibitor, or carbidopa (6.5 mg/kg, s.c.), a peripheral decarboxylase inhibitor, was administered 15 min prior to the dipsogen. Both decarboxylase inhibitors attenuated the dipsogenic response to 5-HTP (25 mg/kg, s.c.) but not to serotonin (2 mg/kg, s.c.). The peripheral serotonergic receptor antagonist, methysergide (3 mg/kg, i.p.), blocked the dipsogenic responses to both 5-HTP (25 mg/kg, s.c.) and serotonin (2 mg/kg, s.c.). There was no interaction between 5-HTP (18 mg/kg, s.c.) and serotonin (1 mg/kg, s.c.) when administered simultaneously with respect to their dipsogenic effects. Thus, the drinking response accompanying administration of 5-HTP occ...Continue Reading

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Citations

Jan 1, 1986·Psychopharmacology·A M Montgomery, M J Burton
Jul 1, 1986·Biological Psychiatry·J D Leander
Jun 1, 1985·Physiology & Behavior·F S KralyM S Trattner
Jun 1, 1981·Pharmacology, Biochemistry, and Behavior·C C BarneyM J Fregly
Sep 1, 1983·Pharmacology, Biochemistry, and Behavior·D C KiktaJ E Greenleaf
Jun 1, 1984·Pharmacology, Biochemistry, and Behavior·P J Fletcher, M J Burton
Jul 1, 1986·Pharmacology, Biochemistry, and Behavior·A M MontgomeryM J Burton
Apr 1, 1986·Pharmacology, Biochemistry, and Behavior·P J Fletcher, M J Burton
Feb 1, 1989·Pharmacology, Biochemistry, and Behavior·O GüntürkünU Zwilling
Jan 1, 1984·Pharmacology & Therapeutics·L M Fuller
Apr 1, 1987·Brain Research Bulletin·N E RowlandM J Fregly
Jan 8, 2000·Physiology & Behavior·L ThibaultC Y Wong
Mar 1, 1994·Pharmacology, Biochemistry, and Behavior·S J Cooper, D J Barber
Aug 16, 2005·Brazilian Journal of Biology = Revista Brasleira De Biologia·L C ReisC M Thomaz
Jul 1, 1984·The American Journal of Physiology·K A CarlbergM Fahey

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