Peripheral corticotropin releasing hormone mediates post-inflammatory visceral hypersensitivity in rats.

World Journal of Gastroenterology : WJG
Jun-Ho LaIl-Suk Yang

Abstract

To investigate whether peripheral corticotropin releasing hormone (CRH), which is up-regulated in intestinal inflammation, mediates the post-inflammatory visceral hypersensitivity in a rat model of colitis. We measured mucosal myeloperoxidase (MPO) activity as a marker of inflammation, plasma CRH level, and abdominal withdrawal reflex (AWR) to colorectal distension as a visceral nociceptive response at 2, 7 and 14 d after the induction of colitis with 4% acetic acid. Colonic inflammation, quantified by MPO activity, significantly increased on d 2 and subsided thereafter, which indicated a resolution of inflammation within 7 d. On the contrary, plasma CRH level and AWR score were increased on d 2, remained high on d 7, and returned to control level on d 14. Intraperitoneal injection of a CRH antagonist, astressin (30 mug/kg), significantly attenuated the post-inflammatory visceral hypersensitivity on d 7. Furthermore, intraperitoneal administration of CRH (3 and 10 mug/kg) mimicked the post-inflammatory visceral hypersensitivity in naive rats. These results suggest that increased peripheral CRH mediates the enhanced visceral nociception in rats recovered from experimental colitis.

Associated Clinical Trials

Jan 16, 2015·Craig A. Friesen, MD

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Citations

Jul 22, 2009·British Medical Bulletin·A D Farmer, Q Aziz
Jun 28, 2012·World Journal of Gastroenterology : WJG·Xian-Zhao YuZhen-Xue Sun
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Feb 12, 2019·Cellular and Molecular Gastroenterology and Hepatology·Wilmarie Morales-Soto, Brian D Gulbransen

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