Abstract
To investigate whether peripheral corticotropin releasing hormone (CRH), which is up-regulated in intestinal inflammation, mediates the post-inflammatory visceral hypersensitivity in a rat model of colitis. We measured mucosal myeloperoxidase (MPO) activity as a marker of inflammation, plasma CRH level, and abdominal withdrawal reflex (AWR) to colorectal distension as a visceral nociceptive response at 2, 7 and 14 d after the induction of colitis with 4% acetic acid. Colonic inflammation, quantified by MPO activity, significantly increased on d 2 and subsided thereafter, which indicated a resolution of inflammation within 7 d. On the contrary, plasma CRH level and AWR score were increased on d 2, remained high on d 7, and returned to control level on d 14. Intraperitoneal injection of a CRH antagonist, astressin (30 mug/kg), significantly attenuated the post-inflammatory visceral hypersensitivity on d 7. Furthermore, intraperitoneal administration of CRH (3 and 10 mug/kg) mimicked the post-inflammatory visceral hypersensitivity in naive rats. These results suggest that increased peripheral CRH mediates the enhanced visceral nociception in rats recovered from experimental colitis.
References
Mar 1, 1983·Gut·B IsgarP J Whorwell
Oct 1, 1995·Gut·Y KawahitoM Kondo
Jul 1, 1995·The Journal of Endocrinology·E A LintonC D Wolfe
Sep 1, 1993·Digestive Diseases and Sciences·A P WestonP B Miner
Aug 1, 1994·Endocrine Journal·T NishiokaK Hashimoto
Sep 1, 1996·Gut·E A van TolR B Sartor
Feb 7, 1998·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M GuéL Buéno
Mar 2, 1999·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·P G McLeanL Buéno
May 9, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·L BuénoR Garcia-Villar
Sep 30, 2000·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M O'SullivanC A O'Morain
Oct 31, 2000·Gastroenterology·E D Al-ChaerP J Pasricha
Nov 15, 2000·Gut·G F Gebhart
Dec 13, 2000·Gastroenterology·C MaillotY Taché
May 5, 2001·Peptides·D S JessopS L Lightman
Jun 8, 2001·News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society·Omri Bauer, Ehud Razin
Apr 19, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Marcel MiampambaYvette Taché
Jun 22, 2002·Gut·G BarbaraR Corinaldesi
Jun 22, 2002·Gut·M Delvaux
Jul 30, 2002·Gastroenterology·Michael WlkCharalabos Pothoulakis
Mar 19, 2003·Alimentary Pharmacology & Therapeutics·H Mertz
Jul 23, 2003·The American Journal of Gastroenterology·Simon P DunlopRobin C Spiller
Dec 12, 2003·World Journal of Gastroenterology : WJG·Jun-Ho LaIl-Suk Yang
Mar 3, 2004·Digestive Diseases and Sciences·J M GschossmannG Holtmann
May 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Pauline M AntonCharalabos Pothoulakis
Jun 15, 2004·Gut·Y SagamiS Fukudo
Jul 6, 2004·Gastroenterology·Premysl BercíkStephen M Collins
May 11, 2005·Proceedings of the National Academy of Sciences of the United States of America·Susanne E la FleurAditi Bhargava
Jul 5, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ines SchwetzEmeran A Mayer
Nov 18, 2005·Gender Medicine·Yvette TachéLixin Wang
Jan 21, 2006·Brain Research·Beverley Greenwood-Van MeerveldDean A Myers
Apr 25, 2006·Pain·Birgit AdamGerald Holtmann
Jun 2, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·N TrimbleB Greenwood-van Meerveld
Jun 15, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J TayamaS Fukudo
Citations
Jul 22, 2009·British Medical Bulletin·A D Farmer, Q Aziz
Jun 28, 2012·World Journal of Gastroenterology : WJG·Xian-Zhao YuZhen-Xue Sun
Aug 24, 2011·Journal of Neurogastroenterology and Motility·Muriel LaraucheYvette Taché
Nov 7, 2009·Gastroentérologie Clinique Et Biologique·L Bueno
Feb 10, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M Larauche
Nov 1, 2013·Cell Biology International·Yongzhi FanYi Cai
May 18, 2011·Experimental Neurology·Muriel LaraucheYvette Taché
Jun 8, 2018·Journal of Neurogastroenterology and Motility·Fatemeh DolatabadiRoja Rahimi
Oct 1, 2011·Molecular and Cellular Biochemistry·Wuchao WangJihong Zhou
Feb 1, 2013·British Journal of Pain·Adam D Farmer, Qasim Aziz
Jul 22, 2019·BMC Anesthesiology·Meng LiangYingna Qiu
Aug 29, 2018·Frontiers in Pharmacology·Fa-Wu DongJiang-Miao Hu
Feb 12, 2019·Cellular and Molecular Gastroenterology and Hepatology·Wilmarie Morales-Soto, Brian D Gulbransen