Peripheral cytokine and fatty acid associations with neuroinflammation in AD and aMCI patients: An exploratory study.

Brain, Behavior, and Immunity
Giulia CisbaniRichard P Bazinet

Abstract

Neuroinflammation is thought to be important in the progression of Alzheimer's disease (AD). To evaluate cerebral inflammation radioligands that target TSPO, a translocator protein strongly expressed in microglia and macrophages during inflammation, can be used in conjunction with positron emission tomography (PET) imaging. In AD patients, neuroinflammation is up-regulated compared to both healthy volunteers as well as to subjects with amnestic Mild Cognitive Impairment. Peripheral biomarkers, such as serum cytokines and total fatty acids (FAs), can also be indicative of the inflammatory state of subjects with neurodegenerative disorders. To understand whether peripheral biomarkers are predictive of neuroinflammation we conducted a secondary exploratory analysis of two TSPO imaging studies conducted in subjects with AD, aMCI and aged matched healthy volunteers. We examined the association between candidate peripheral biomarkers (including amyloid beta, cytokines and serum total fatty acids) with brain TSPO levels. Our results showed that serum IL-6 and IL-10 are higher in AD compared to the aMCI and healthy volunteers while levels of some fatty acids are modulated during the disease. A limited number of associations were observ...Continue Reading

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Citations

Jul 15, 2020·Biomolecules·Chiara PorroMaria Antonietta Panaro
Jun 9, 2020·Brain, Behavior, and Immunity·Brittany N Dugger, Ameer Y Taha
Dec 4, 2020·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Giulia Cisbani, Richard P Bazinet
Jan 21, 2021·International Journal of Environmental Research and Public Health·Robert D DanielsDori B Reissman
Mar 14, 2021·Molecular Neurobiology·Peng-Fei ZhangJin-Tai Yu
Apr 16, 2021·Molecular Psychiatry·Giulia Cisbani, Serge Rivest

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