PMID: 3746288Jan 1, 1986Paper

Peripheral distribution of free dopamine and its metabolites in the rat

Journal of Neural Transmission
R FavreL Peyrin

Abstract

Free dopamine (DA) and its metabolites, homovanillic acid (HVA) and 3-4 dihydroxyphenylacetic acid (DOPAC), have been measured and compared with norepinephrine (NE) concentrations in rat peripheral tissues using high performance liquid chromatography with electrochemical detection (HPLC-ED). Detectable amounts of DA and its metabolites were found in all the analyzed tissues. The highest levels were found in carotid body, sympathetic ganglia, urogenital tract and heart, the lowest in liver and lung. DA and DOPAC distribution was heterogeneous and unrelated to NE concentration. Both the variable value of the DA/DA+NE ratio and the presence of DA metabolites in peripheral tissues indicate that a portion of DA may be stored outside noradrenergic neurons and directly catabolized in specific DA pools.

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Citations

Jan 1, 1992·Journal of Neural Transmission. General Section·R Favre-MauriceL Peyrin
Aug 1, 1993·Biological Psychiatry·A L MillerJ Castiglioni
May 9, 2000·Progress in Neuro-psychopharmacology & Biological Psychiatry·F DuvalJ P Macher
Aug 26, 1998·Fundamental & Clinical Pharmacology·C CommunalP Demenge
Nov 18, 1998·Fundamental & Clinical Pharmacology·C CommunalP Demenge
May 1, 1990·Journal of Neurochemistry·E W KristensenG M Tyce
May 12, 2019·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·S M Matt, P J Gaskill
Mar 3, 2010·International Journal of Environmental Research and Public Health·Julius FobilAlexander Kraemer
May 5, 2011·The American Journal of Tropical Medicine and Hygiene·Tarig B HigaziFrank Richards
Jun 1, 1996·The Journal of Pharmacy and Pharmacology·N KurokawaC Yanaihara
Aug 1, 1995·The Journal of Pharmacy and Pharmacology·M KodobayashiN Kurokawa
Sep 1, 1991·British Journal of Clinical Pharmacology·T L SchwinghammerR K Shadduck
Mar 1, 1989·Journal of Clinical Pharmacology·J GrevelB D Kahan
May 20, 2003·Journal of Applied Physiology·Lars NyboNiels Secher

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