Peripheral endothelial dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome.

ESC Heart Failure
Nadja ScherbakovCarmen Scheibenbogen

Abstract

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex multisystem disease. Evidence for disturbed vascular regulation comes from various studies showing cerebral hypoperfusion and orthostatic intolerance. The peripheral endothelial dysfunction (ED) has not been sufficiently investigated in patients with ME/CFS. The aim of the present study was to examine peripheral endothelial function in patients with ME/CFS. Thirty-five patients [median age 40 (range 18-70) years, mean body mass index 23.8 ± 4.2 kg/m2 , 31% male] with ME/CFS were studied for peripheral endothelial function assessed by peripheral arterial tonometry (EndoPAT2000). Clinical diagnosis of ME/CFS was based on Canadian Criteria. Nine of these patients with elevated antibodies against β2-adrenergic receptor underwent immunoadsorption, and endothelial function was measured at baseline and 3, 6, and 12 months follow-up. ED was defined by reactive hyperaemia index ≤1.81. Twenty healthy subjects of similar age and body mass index were used as a control group. Peripheral ED was found in 18 of 35 patients (51%) with ME/CFS and in 4 healthy subjects (20%, P < 0.05). Patients with ED, in contrast to patients with normal endothelial function, reported more ...Continue Reading

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Citations

Aug 6, 2020·Journal of Clinical Medicine·Markus TölleCarmen Scheibenbogen
Oct 30, 2020·Journal of Clinical Medicine·Sławomir KujawskiPaweł Zalewski
Feb 21, 2021·European Journal of Heart Failure·Daniela Tomasoni, Andrew J S Coats
Mar 7, 2021·International Journal of Environmental Research and Public Health·Joshua BondLynette Hodges
Apr 23, 2021·Journal of Translational Medicine·Klaus J Wirth, Carmen Scheibenbogen
Apr 21, 2021·Journal of Translational Medicine·Bianka JäkelHelma Freitag
May 21, 2021·Scientific Reports·J BlauensteinerF Westermeier
Jul 13, 2021·Frontiers in Cellular Neuroscience·Adonis SferaZisis Kozlakidis

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Methods Mentioned

BETA
ELISA

Software Mentioned

SPSS Statistics
GraphPad Prism

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