Peripheral endothelial function is positively associated with maximal aerobic capacity in patients with chronic obstructive pulmonary disease

Respiratory Medicine
Anouk W VaesPatrick De Boever

Abstract

Patients with COPD are frequently diagnosed with cardiovascular disease. Peripheral endothelial dysfunction is an underlying mechanism and can be used as an early marker of cardiovascular impairment. To date, little is known on the association between peripheral endothelial dysfunction, cardiovascular risk factors and measurements of exercise capacity in patients with COPD. Therefore, we aimed to determine the relation between endothelial function and patient characteristics, cardiovascular risk factors and (micro)vascular and functional performance in patient with CODP. Clinical and demographic data of patients with COPD were measured during routine pre-rehabilitation assessment. Cardiovascular risk factors, including blood pressure, ankle brachial index, arterial stiffness and retinal vessel widths were obtained. Peripheral endothelial function was measured using the EndoPAT-2000. Functional performance was assessed using cardiopulmonary exercise test, constant work rate test and six-minute walk test. 40 patients with COPD completed the study protocol (65% males; mean age: 62.8 ± 7.3 years; mean FEV1: 45.8 ± 17.5 %pred). Peripheral endothelial dysfunction was observed in 55% of the patients. Patients with peripheral endotheli...Continue Reading

Citations

Dec 29, 2019·Physiotherapy Research International : the Journal for Researchers and Clinicians in Physical Therapy·Cintia Laura Pereira de AraujoPedro Dal Lago
Nov 29, 2020·Respiratory Medicine·Dario KohlbrennerNoriane A Sievi
Apr 21, 2021·Expert Review of Respiratory Medicine·Marieta P TheodorakopoulouAfroditi K Boutou

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