Peripheral enhancement and spatial contrast uptake heterogeneity of primary breast tumours: quantitative assessment with dynamic MRI

Journal of Computer Assisted Tomography
S MussurakisA Horsman

Abstract

The purpose of our study was to determine if quantitative analysis of peripheral enhancement and spatial contrast uptake heterogeneity is useful in the characterisation of abnormalities seen at breast MRI. Ninety-one women underwent dynamic gadolinium-enhanced breast MRI. Regions of interest were processed by a parallel thinning algorithm to define central and peripheral subregions of lesions. Peripheral enhancement was quantified at every time point of the dynamic sequence as a signal difference-to-noise ratio. Moreover, a radiologist assessed the images for the presence of peripheral enhancement and classified the regional and subregional time-intensity profiles of each lesion. Sixty-four invasive carcinomas and 30 benign lesions were analysed. Significant differences were found between benign and malignant lesions in peripheral enhancement as determined from the dynamic images (p = 0.0002; sensitivity, 0.34; specificity, 1.00) in time-intensity profiles (p < 0.000005; sensitivity, 0.67; specificity, 0.93) and in peripheral percentage signal changes at 1 min postcontrast (p = 0.001). There was a much higher relative signal increase centrally than peripherally (p < 0.0005), but peripheral signal changes had greater diagnostic ...Continue Reading

References

Jan 1, 1992·Acta Oncologica·I S GribbestadS Kvinnsland
Jan 3, 1991·The New England Journal of Medicine·N WeidnerJ Folkman
Jan 27, 1990·BMJ : British Medical Journal·J N MatthewsP Royston
Nov 1, 1990·The British Journal of Surgery·T K WaltersM Burke
Apr 1, 1989·Radiology·S H HeywangW Permanetter
Apr 1, 1982·Scandinavian Journal of Clinical and Laboratory Investigation·H WiigL Weiss
Apr 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·U HoffmannW J Lorenz
Nov 1, 1996·The British Journal of Radiology·S MussurakisA Horsman
Jan 1, 1997·Radiology·S D Wolff, R S Balaban
Mar 1, 1997·Radiology·L W NunesM H Torosian
May 1, 1997·Journal of Computer Assisted Tomography·S MussurakisA Horsman

❮ Previous
Next ❯

Citations

Dec 3, 1999·Journal of Magnetic Resonance Imaging : JMRI·G P LineyL W Turnbull
May 31, 2001·Journal of Magnetic Resonance Imaging : JMRI·E Furman-HaranH Degani
Dec 27, 2005·Medical Molecular Morphology·Ritsu KusamaShin-ichi Tsuchiya
Nov 1, 2001·Topics in Magnetic Resonance Imaging : TMRI·G Schneider, K Altmeyer
Nov 20, 2003·Topics in Magnetic Resonance Imaging : TMRI·Guenther Schneider, Michael Uder
Jun 24, 2005·Investigative Radiology·Dorothee R FischerWerner A Kaiser
Jul 25, 2006·AJR. American Journal of Roentgenology·Dorothee R FischerWerner A Kaiser
Jul 25, 2006·AJR. American Journal of Roentgenology·Hiroyuki NarisadaYukunori Korogi
Aug 22, 2009·AJR. American Journal of Roentgenology·Lilian C WangConstance D Lehman
Mar 7, 2006·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Megumi JingujiHiroki Yoshida
Oct 12, 2000·The British Journal of Radiology·S C Rankin
Nov 9, 2010·International Journal of Pharmaceutics·Ahmed BesheerKarsten Mäder
Jul 23, 2011·Journal of Experimental & Clinical Cancer Research : CR·Henrike CaysaThomas Mueller
Apr 26, 2014·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Man ChenXiao-chun Fei
Sep 26, 2003·Journal of Magnetic Resonance Imaging : JMRI·Milica MedvedGregory S Karczmar
Feb 7, 2008·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Shin Ho LeeWoo Kyung Moon

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.