Peripheral fatigue: high-energy phosphates and hydrogen ions

PM & R : the Journal of Injury, Function, and Rehabilitation
Randall E Keyser

Abstract

Peripheral fatigue results from an overactivity-induced decline in muscle function that originates from non-central nervous system mechanisms. A common symptom of fatigue is a feeling of tiredness or weariness because of overexertion, such as that associated with intense or prolonged physical exercise. Fatigue is worsened by low physical fitness and chronic illnesses. These conditions may intensify fatigue to levels that limit physical and social functioning and severely diminish health-related quality of life. Although etiologic aspects of peripheral fatigue are often associated with regulatory system (neurologic, endocrine, immunologic, muscular) and support system (cardiovascular, pulmonary, metabolic, renal, digestive, skeletal) limitations, final mediation occurs in muscle cells as a result of altered crossbridge functioning. Specifically, the final product and ionic metabolite accumulation that result from adenosine triphosphate hydrolysis appear to inhibit crossbridge formation and activation. Thus, clinical manifestations of peripheral fatigue often can be observed as limitations placed upon muscle or cardiorespiratory endurance, here defined as fatigue resistance. An overview of the common pathways by which peripheral ...Continue Reading

References

Feb 1, 1992·Journal of Applied Physiology·H J GreenB Farrance
Aug 15, 1992·The American Journal of Cardiology·J R WilsonM Simson
Jan 31, 1992·Biochemistry·J W HanL M Heilmeyer
Nov 1, 1989·The Journal of Physiology·E B CadyA Moll
Aug 1, 1986·Pflügers Archiv : European journal of physiology·G C Elder, F Vassallo
Jun 1, 1988·Journal of Applied Physiology·J R WilsonB Chance
Jan 1, 1987·European Journal of Applied Physiology and Occupational Physiology·J HirvonenM Härkönen
Aug 1, 1987·Pflügers Archiv : European journal of physiology·H BaumannM C Schaub
Sep 1, 1966·Journal of Applied Physiology·A Holmgren, P O Astrand
Jun 25, 1980·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·M J DawsonD R Wilkie
Feb 1, 1982·International Journal of Sports Medicine·H Howald
Apr 15, 1982·Archives of Biochemistry and Biophysics·K J DaviesG A Brooks
Jul 1, 1981·Archives of Biochemistry and Biophysics·K J DaviesG A Brooks
Jul 1, 1995·Experimental Physiology·D G AllenH Westerblad
Apr 1, 1995·International Journal of Sports Medicine·P Korge, K B Campbell
Jan 1, 1994·Physiological Reviews·R H Fitts
Apr 1, 1997·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·I MargaritisJ F Marini
Mar 12, 1998·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·P D ChilibeckT Martin
Nov 18, 2000·Archives of Physical Medicine and Rehabilitation·R E KeyserJ Anixt
Aug 4, 2001·Pflügers Archiv : European journal of physiology·C KaratzaferiA J Sargeant
Oct 24, 2002·Acta Physiologica Scandinavica·J P WahrmannA T Dinh-Xuan
Feb 13, 2003·Arthritis and Rheumatism·Randall E KeyserBarry S Handwerger
Mar 29, 1954·The Journal of Physiology·P A MERTON
Oct 14, 2003·European Journal of Applied Physiology·Bruno Grassi
May 7, 2004·American Journal of Physiology. Cell Physiology·E P DeboldR H Fitts
Jul 30, 2004·American Journal of Physiology. Cell Physiology·Robyn M MurphyGraham D Lamb
Aug 31, 2004·Journal of Applied Physiology·Neeti PathareKrista Vandenborne
Mar 27, 2007·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Hiroshi Kagawa
Oct 27, 2007·Journal of Applied Physiology·D G AllenH Westerblad
Dec 14, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Christina KaratzaferiRoger Cooke
Dec 29, 2007·Journal of Applied Physiology·Robert H Fitts

❮ Previous
Next ❯

Citations

Jun 6, 2012·Disability and Rehabilitation·Svetlana KnorrS Jayne Garland
Jun 15, 2012·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Hong-You GePascal Madeleine
Jul 27, 2010·PM & R : the Journal of Injury, Function, and Rehabilitation·Lynn H Gerber
Sep 17, 2013·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Preethi Thiagarajan, Kenneth J Ciuffreda
Jun 23, 2015·Journal of the International Society of Sports Nutrition·Peter KrustrupMagni Mohr
Aug 29, 2018·Journal of Neural Engineering·Henry ShinXiaogang Hu
May 3, 2013·Nature Reviews. Neuroscience·Vladyslav V Vyazovskiy, Kenneth D Harris
Dec 13, 2012·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Preethi Thiagarajan, Kenneth J Ciuffreda
Dec 19, 2019·Integrated Environmental Assessment and Management·Florence Barbara AwinoA Jasmyn J Lynch
Nov 23, 2019·Nutrición hospitalaria·Ignacio Escribano Ott, Javier Ibáñez Santos
Dec 1, 2011·Biophysics Reviews·Justin M Percival
Nov 9, 2020·Drug Testing and Analysis·Simon R BaileyCatherine M Steel
Jan 21, 2021·Journal of Functional Morphology and Kinesiology·Andrew E PechsteinAndrew A Guccione
Feb 5, 2021·Topics in Spinal Cord Injury Rehabilitation·Donal MurrayRandall E Keyser
Feb 7, 2021·International Journal of Biological Macromolecules·Wen-Di ShenJian-Ping Luo
Jun 24, 2021·Revista da Associação Médica Brasileira·Igor NasserMichel Silva Reis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Homeostasis

Cardiovascular regulation and homeostasis is important in maintaining health and dysfunction may lead to cardiovascular diseases. Nitric oxide and vascular endothelium are one of many molecules involved in the homeostatic mechanism. Here is the latest research on cardiovascular homeostasis.

Cellular Immunometabolism

Immunometabolism involves not only the way metabolites are digested by the immune system, but the way in which they can alter the pathway of the immune system. These responses occur in day-to-day healthy cell functioning, but can result in diseases, such as autoimmune disorders. Discover the latest research on cellular immunometabolism here.

Related Papers

Sports Medicine
Wim Ament, Gijsbertus J Verkerke
PM & R : the Journal of Injury, Function, and Rehabilitation
Victoria M Leavitt, John DeLuca
PM & R : the Journal of Injury, Function, and Rehabilitation
Marni N SilvermanEsther M Sternberg
Electroencephalography and Clinical Neurophysiology
Lars Arendt-Nielsen, K R Mills
© 2021 Meta ULC. All rights reserved