Peripheral fractional oxygen extraction and other measures of tissue oxygenation to guide blood transfusions in preterm infants

Seminars in Perinatology
S P Wardle, A M Weindling

Abstract

The physiological effects of anemia in the preterm infant are complex and the indications for transfusions in preterm infants are controversial. A measure of the adequacy of tissue oxygenation may be a better guide to the need for transfusions than currently used criteria. This article considers 2 measures of tissue oxygenation of preterm infants: 1) The whole blood lactate concentration, and 2) Peripheral fractional oxygen extraction (FOE) by using near infrared spectroscopy. Several studies have shown falls in blood lactate concentration after blood transfusion, but it has been difficult to establish a convincing link between raised lactate concentrations and significant anemia because even anemic infants have lactate concentrations that are within or close to the normal range. Lactate concentrations may be affected by the haematocrit of the blood sample. Peripheral FOE can be measured by using near infrared spectroscopy with partial venous occlusion and has been studied in preterm infants with symptomatic and asymptomatic anaemia. Mean (SD) FOE was significantly higher in symptomatic [0.425 (0.06)] (P< .01) but not asymptomatic [0.334 (0.05)] compared to controls [0.352 (0.06)], (P = .22). After transfusion there was a signi...Continue Reading

References

Nov 1, 1978·Archives of Disease in Childhood·C A WardropO P Gray
Feb 1, 1977·The Journal of Pediatrics·G FaxeliusM Stahlman
Mar 24, 1977·The New England Journal of Medicine·J A StockmanF A Oski
Apr 1, 1992·The Journal of Pediatrics·R D ChristensenG Rothstein
Jan 1, 1990·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·R K Whyte
Jan 1, 1990·Intensive Care Medicine·J A Kruse, R W Carlson
Jul 1, 1990·Archives of Disease in Childhood·I HudsonC A Wardrop
Oct 1, 1987·Archives of Disease in Childhood·N R Roberton
Jul 1, 1997·Medical & Biological Engineering & Computing·C W Yoxall, A M Weindling

❮ Previous
Next ❯

Citations

Jan 21, 2010·Current Opinion in Pediatrics·Moira Crowley, Haresh Kirpalani
Feb 24, 2004·Archives of Disease in Childhood. Fetal and Neonatal Edition·N A Murray, I A G Roberts
Mar 12, 2010·Early Human Development·Michael Weindling, Fauzia Paize
Jul 22, 2008·Early Human Development·Naomi L C Luban
May 22, 2007·Early Human Development·Patrizia ZaramellaLino Chiandetti
May 3, 2015·Seminars in Fetal & Neonatal Medicine·Beena G SoodJosef Cortez
May 8, 2009·Pediatrics International : Official Journal of the Japan Pediatric Society·Daijiro TakahashiAkira Shirahata
May 7, 2014·Transfusion·Jayanta Banerjee, Narendra Aladangady
Apr 19, 2018·Transfusion Medicine·G L CrightonS J Stanworth
Jun 24, 2004·Vox Sanguinis·N L C Luban
Mar 20, 2018·Neonatology·Claire HowarthNarendra Aladangady
Aug 9, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Sara ErolAhmet Yagmur Bas
May 12, 2016·Journal of Biomedical Optics·Sean M Bailey, Pradeep V Mally
May 26, 2005·Journal of Perinatology : Official Journal of the California Perinatal Association·Patrizia ZaramellaLino Chiandetti
Oct 24, 2002·Current Opinion in Hematology·Naomi L C Luban
Feb 17, 2017·Iranian Journal of Pediatrics·Mohammad-Reza AlipourZohreh Pezeshkpour
Sep 27, 2018·Journal of Perinatology : Official Journal of the California Perinatal Association·Emily A MorrisLori C Jordan
May 24, 2014·Paediatrics & Child Health·Robin K WhyteUNKNOWN Canadian Paediatric Society, Fetus and Newborn Committee
Apr 12, 2019·Neonatology·Haresh Kirpalani, Robin K Whyte

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.