Peripheral H1-blockade effect of fexofenadine

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
F E Simons, K J Simons

Abstract

Studies of the suppressive effect of H1-receptor antagonists on the histamine-induced wheal and flare are useful for assessing peripheral H1-blockade. To compare the peripheral H1-blockade produced by fexofenadine, 60 mg twice daily or 120 mg once daily; loratadine, 10 mg once daily; and placebo during 24 hours. In this randomized, double-blind, single-dose, crossover study in 20 subjects, the wheals and flares produced by epicutaneous tests with histamine phosphate 1 mg/mL were measured before and at intervals (20, 40, 60 minutes, hourly until 12 hours, and 24 hours) after the ingestion of fexofenadine, 60 mg twice daily; fexofenadine, 120 mg once daily; loratadine, 10 mg once daily; or placebo. All active medications effectively suppressed the histamine-induced wheal and flare for 24 hours compared with placebo. Fexofenadine 60 mg twice daily and fexofenadine 120 mg once daily had a faster onset of action than loratadine in this experimental model. Peripheral H1-blockade studies are useful for investigation of the differences among H1-receptor antagonists. They complement large clinical trials in which efficacy is subjectively assessed using symptom scores, and which are more likely to demonstrate similarities among the diffe...Continue Reading

References

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Dec 22, 2004·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Ashok PurohitNelly Frossard
May 2, 2003·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Fran Ridout, Ian Hindmarch
Jul 4, 2003·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Michael A KalinerSuzanne G Meeves
Sep 25, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Juan GispertXavier Luria
Feb 24, 2001·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·F E SimonsK J Simons
May 10, 2001·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·A PurohitN Frossard
Jun 1, 2000·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·H S NelsonJ Mason
May 10, 2006·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Yoshihiro OhashiKiyotaka Murata
Jul 11, 2000·Allergy·N Frossard, G M Walsh
May 11, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·I HindmarchS Kimber
Oct 23, 2002·International Journal of Dermatology·Makoto KawashimaToshiro Tango
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May 18, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Ceren Börçek KasurkaVedat Sekeroğlu
Feb 14, 2018·International Forum of Allergy & Rhinology·Sarah K WiseMark Zacharek
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Mar 10, 2001·The Journal of Allergy and Clinical Immunology·F E SimonsK J Simons
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