Peripheral immune factors are elevated in women with current or recent alcohol dependence and associated with altered mood and memory

Drug and Alcohol Dependence
Clare J WilhelmJennifer M Loftis

Abstract

The adverse effects of alcohol on brain function result, in part, from inflammatory processes. The sex-specific neuropsychiatric consequences and inflammatory status of active alcohol dependence and early remission from dependence have not been investigated. Neuropsychiatric symptoms, inflammatory factors, and liver enzymes were compared in a prospective cohort study of adults with (n=51) or without (n=31) a current or recent history of alcohol dependence. Neuropsychiatric profiles were similar in adults with current or recent alcohol dependence regardless of sex. In male and female participants measures of depression (female p<0.05, male p<0.001), anxiety (female p<0.001, male p<0.001), and memory complaints (female p<0.001, male p<0.05) were elevated, relative to non-dependent controls. Significant sex×alcohol dependence history interactions were observed for plasma levels of tissue inhibitor of metalloproteinase 1 (TIMP-1) and brain derived neurotrophic factor (BDNF), with women in the alcohol dependent group exhibiting increased levels of both analytes (p<0.05) relative to controls. Positive correlations between TIMP-1 levels and measures of depression (r2=0.35, p<0.01), anxiety (r2=0.24, p<0.05) and memory complaints (r2=0...Continue Reading

Citations

Dec 19, 2019·Annals of the ICRP·F PaquetJ D Harrison
Mar 20, 2019·Journal of Neuroendocrinology·Florent PittetBenjamin C Nephew
Apr 25, 2018·Neuroscience Letters·Milky KohnoWilliam F Hoffman
Jul 23, 2021·Journal of Neuroscience Research·Ursula S Sandau, Jennifer M Loftis

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