Peripheral Immune Profile and Neutrophil-to-Lymphocyte Ratio in Parkinson's Disease.

Movement Disorders : Official Journal of the Movement Disorder Society
Laura Muñoz-DelgadoPablo Mir

Abstract

The neutrophil-to-lymphocyte ratio (NLR) in peripheral blood is a well-established inflammatory marker, but its role in Parkinson's disease (PD) remains unclear. To determine whether a different peripheral immune profile and NLR were present in PD patients. We conducted a case-control study that included 377 PD patients and 355 healthy controls (HCs). Leukocytes, subpopulations, and the NLR were measured. Multivariate linear regression analyses were applied to determine the differences between groups and the association between NLR and clinical characteristics in PD. A meta-analysis was performed to clarify the association between NLR and PD. In our case-control study, the NLR was significantly higher in PD patients compared with HCs (2.47 ± 1.1 vs. 1.98 ± 0.91, P < 0.001). No association between NLR and age at onset, disease severity, or disease duration was found. The meta-analysis showed that the NLR was likely to be higher in PD patients. PD patients had an altered peripheral immune profile and a higher NLR compared with HCs. © 2021 International Parkinson and Movement Disorder Society.

References

Jan 4, 2001·Journal of Neuroimmunology·J BasE Buendia
Dec 29, 2004·Journal of Clinical Immunology·Joana VitteJean-Louis Gastaut
Nov 10, 2009·Brain, Behavior, and Immunity·Chandrani SarkarSujit Basu
Aug 23, 2012·Journal of Neuroimmunology·Claire H StevensGlenda M Halliday
Apr 1, 2014·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Natasa KustrimovicMarco Cosentino
May 14, 2014·BioMed Research International·Xiaomin Su, Howard J Federoff
Oct 8, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Eşref AkılMehmet Ufuk Aluçlu
Oct 17, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Ronald B PostumaGünther Deuschl
Nov 12, 2016·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ceyla Ataç UçarTahir Kurtuluş Yoldaş
Jan 7, 2017·BMC Research Notes·Patrice ForgetMarc De Kock
Mar 14, 2017·Nature Reviews. Immunology·Oliver SoehnleinChristian Weber
May 13, 2017·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Sen JiangXinling Yang
Sep 10, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·J A ObesoA J Stoessl
Nov 21, 2018·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Ryul KimBeomseok Jeon
Nov 27, 2018·The European Journal of Neuroscience·Malú G Tansey, Marina Romero-Ramos
Apr 4, 2019·Frontiers in Neurology·Marie Therese Fuzzati-ArmenteroFabio Blandini
May 10, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ashley B PetroneMatthew J Zdilla
Aug 27, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Sara Konstantin NissenMarina Romero-Ramos
Nov 13, 2019·Journal of Neuroinflammation·Diana D Álvarez-LuquínLaura Adalid-Peralta
Dec 23, 2019·Journal of the Neurological Sciences·Tadashi UmeharaHidetomo Murakami
Dec 24, 2019·Frontiers in Aging Neuroscience·Xiaoyu DongDongming Zheng
Jan 5, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ipek InciNeslihan Eskut
Apr 16, 2020·Statistical Methods in Medical Research·Sean McGrathUNKNOWN DEPRESsion Screening Data (DEPRESSD) Collaboration
Apr 26, 2020·Nature Reviews. Neurology·Eng-King TanJoseph Jankovic
May 2, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Etienne C Hirsch, David G Standaert
Jul 20, 2020·Neuroscience Letters·Hong JinChun-Feng Liu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.