Peripheral inflammation during abnormal mood states in bipolar I disorder

Journal of Affective Disorders
Jess G FiedorowiczJohn A Wemmie

Abstract

Bipolar disorder carries a substantive morbidity and mortality burden, particularly related to cardiovascular disease. Abnormalities in peripheral inflammatory markers, which have been commonly reported in case-control studies, potentially link these co-morbidities. However, it is not clear whether inflammatory markers change episodically in response to mood states or are indicative of chronic pro-inflammatory activity, regardless of mood, in bipolar disorder. Investigations focused on comparing concentrations of specific inflammatory cytokines associated with immune activation status (primary outcome=tumor necrosis factor alpha (TNF-α)) in 37 participants with bipolar disorder across 3 mood states (mania N=15, depression N=9, normal mood N=13) and 29 controls without a psychiatric disorder (total N=66). Cytokine levels were also compared to T1ρ, a potential neuroimaging marker for inflammation, in select brain regions in a subsample (N=39). Participants with bipolar disorder and healthy controls did not differ significantly in inflammatory cytokine concentrations. However, compared to cases with normal mood, cases with abnormal mood states (mania and depression) had significantly elevated levels of TNF-α, its soluble receptors...Continue Reading

References

Jun 1, 1996·Computers and Biomedical Research, an International Journal·R W Cox
May 24, 2003·Psychosomatic Medicine·Marion DannerViola Vaccarino
Apr 15, 2004·Journal of Neuroimmunology·Hsing-Cheng LiuSy-Jye Leu
Oct 16, 2004·Psychiatry and Clinical Neurosciences·Kyung Heup AhnPerry F Renshaw
Jan 18, 2006·Journal of Affective Disorders·Sinead M O'BrienTimothy G Dinan
May 2, 2006·The British Journal of Psychiatry : the Journal of Mental Science·Sinead M O'BrienTimothy G Dinan
Mar 30, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Faith DickersonRobert Yolken
Sep 12, 2007·Bipolar Disorders·Abigail Ortiz-DomínguezLenin Pavón
Dec 13, 2007·Nature Reviews. Neuroscience·Robert DantzerKeith W Kelley
Feb 26, 2008·European Archives of Psychiatry and Clinical Neuroscience·Angelo B CunhaFlávio Kapczinski
Mar 3, 2009·Journal of Affective Disorders·Elisa BrietzkeFlávio Kapczinski
Jun 30, 2009·Psychosomatic Medicine·Jess G FiedorowiczWilliam H Coryell
Nov 10, 2009·Neuroscience and Biobehavioral Reviews·Katie MahonPhilip R Szeszko
Jun 12, 2010·Journal of Affective Disorders·Sinan GuloksuzDavid J Nutt
Jul 6, 2010·NeuroImage·Ronald PiersonVincent A Magnotta
Aug 6, 2011·Nature Reviews. Immunology·Michael R Irwin, Steven W Cole
May 16, 2012·European Archives of Psychiatry and Clinical Neuroscience·Izabela Guimarães BarbosaAntônio Lúcio Teixeira
Aug 2, 2012·Journal of Psychosomatic Research·Simrit K SodhiJess G Fiedorowicz
Feb 20, 2013·Biological Psychiatry·Amirhossein ModabberniaMandana Ashrafi
Jun 19, 2013·Journal of Psychiatric Research·Klaus MunkholmMaj Vinberg
Sep 5, 2013·Medical Image Analysis·Juan Eugenio IglesiasKoen Van Leemput
Oct 1, 2013·Journal of Psychiatric Research·Izabela Guimarães BarbosaLirlândia Pires de Sousa
Feb 28, 2014·Bipolar Disorders·Emeline MarlingeJosselin Houenou
Mar 4, 2014·Journal of Affective Disorders·Izabela Guimaraes BarbosaAntônio Lucio Teixeira
Apr 22, 2014·Psychosomatics·Jess G FiedorowiczWilliam H Coryell
Aug 21, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alan R ProssinJon-Kar Zubieta

❮ Previous
Next ❯

Citations

Feb 7, 2016·Translational Research : the Journal of Laboratory and Clinical Medicine·Lawrence B Afrin
Jun 28, 2016·Journal of Affective Disorders·Seline van den AmeeleManuel Morrens
Sep 13, 2016·Cytokine & Growth Factor Reviews·Alma Y Galvez-ContrerasOscar Gonzalez-Perez
Oct 25, 2016·The Journal of Nutritional Biochemistry·Sergio Montserrat-de la PazBeatriz Bermudez
Nov 9, 2016·Journal of Psychiatric Research·Ya-Wen ChangSimon J Evans
Nov 9, 2016·Translational Psychiatry·N Mechawar, J Savitz
Aug 9, 2017·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Izabela G BarbosaAntônio L Teixeira
Aug 17, 2018·The British Journal of Psychiatry : the Journal of Mental Science·Tobias RowlandSteven Marwaha
Feb 13, 2016·Chonnam Medical Journal·Ather Muneer
Aug 22, 2018·Frontiers in Physiology·Thomas Larrieu, Sophie Layé
Apr 1, 2019·Heart and Mind·Jonathan W BirdsallJess G Fiedorowicz
Jul 5, 2017·Brain Imaging and Behavior·Joseph J ShafferVincent A Magnotta
Dec 13, 2018·Frontiers in Psychiatry·Artur ReginiaJerzy Samochowiec
Jun 14, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Caroline MénardScott J Russo
Feb 6, 2018·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Pamela FerrariFlorencia M Barbé-Tuana
Apr 4, 2018·Molecular Neurobiology·Michael Maes, Andre F Carvalho
Apr 13, 2020·Brain, Behavior, and Immunity·Błażej MisiakBartłomiej Stańczykiewicz
Feb 7, 2021·International Journal of Molecular Sciences·Kosma Sakrajda, Aleksandra Szczepankiewicz
Nov 11, 2021·Expert Opinion on Therapeutic Targets·Sunghark Kwon, So Yeong Cheon

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.