Peripheral insulin resistance in patients with Behçet's disease

Journal of the European Academy of Dermatology and Venereology : JEADV
H ErdemM Turan

Abstract

In this study, we examined peripheral insulin resistance in patients with Behçet's disease (BD) characterized by chronic inflammation and endothelial dysfunction. Fourteen patients with BD and 15 healthy controls were recruited to the study. Insulin resistance was investigated by the hyperinsulinaemic-euglycaemic glucose clamp technique. BD patients displayed an enhanced rate of insulin resistance compared to healthy controls (P = 0.014). The insulin sensitivity (M), measured as the glucose utilization rate under steady-state conditions of euglycaemia, was significantly decreased (P = 0.001) in BD patients compared to the controls (4.09 +/- 0.16 vs. 5.60 +/- 0.27 mg/kg/min). The C-reactive protein (CRP) level, but not the erythrocyte sedimentation rate (ESR), was significantly related to the presence of insulin resistance (CRP: r(s) = 0.589, P = 0.27; ESR: r(s) = 0444, P = 0112), whereas no relationship was found between the M-value and ESR or CRP. We conclude that patients with BD exhibit peripheral insulin resistance; this could be explained as the diverse consequences of inflammation and endothelial dysfunction in BD.

References

Jan 1, 1977·Scandinavian Journal of Rheumatology·K KootaO Mutru
Jan 1, 1975·Annual Review of Medicine·W R Beisel
Feb 1, 1976·The American Journal of Medicine·M B UrowitzM A Ogryzlo
Sep 1, 1991·Metabolism: Clinical and Experimental·G PaolissoF D'Onofrio
Jan 1, 1990·Annals of the New York Academy of Sciences·H O Besedovsky, A Del Rey
May 1, 1989·Diabetes·V A KoivistoK Cantell
Feb 1, 1988·Metabolism: Clinical and Experimental·K L SvensonR Hällgren
Nov 1, 1987·British Journal of Orthodontics·H S Orton
Jun 15, 1985·British Medical Journal·O MutruK Koota
Sep 20, 1973·The New England Journal of Medicine·E J RayfieldW R Beisel
Oct 1, 1995·The American Journal of Medicine·M B Davidson
Aug 1, 1993·Arthritis and Rheumatism·L T JacobssonP H Bennett
May 1, 1993·Clinical Immunology and Immunopathology·A O AydìntugG R Hughes
Nov 30, 1996·BMJ : British Medical Journal·A J Krentz
Sep 1, 1997·Diabetes·J H PinkneyJ S Yudkin
Feb 23, 1999·Dermatology : International Journal for Clinical and Investigative Dermatology·A OremM Malkoç
Apr 21, 1999·The British Journal of Ophthalmology·N YawataS Ohno
Feb 24, 2001·Journal of the American College of Cardiology·J C ChambersJ S Kooner
Oct 9, 2002·Scandinavian Journal of Rheumatology·Kamel HamzaouiKhaled Ayed
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·I Juhan-VagueP E Morange

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Citations

Oct 28, 2014·Clinical Oral Investigations·Z TakciS G Bilgili
Jan 6, 2012·Pathology Research International·Onur Ozhan, Kerem Sezer
Dec 30, 2014·Journal of Clinical Laboratory Analysis·Fatma Baskaya DoganIlker Erden
Mar 10, 2010·Journal of Internal Medicine·R H StraubG Pongratz
Feb 20, 2008·Journal of Neurology·Oliver Kastrup, Hans Christoph Diener
Apr 30, 2016·Oral Diseases·Murat SereflicanBetul Kizildag
Nov 1, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·E ŞahinE Şavk
Jun 5, 2021·Journal of Cosmetic Dermatology·Filiz Cebeci KahramanNahide Onsun

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